Correlation between genioglossal and diaphragmatic responses to hypercapnia during sleep.
Correlation between genioglossal and diaphragmatic responses to hypercapnia during sleep.
复制标题
睡眠期间颏舌肌和膈肌对高碳酸血症的反应之间的相关性。
DOI：
10.1164/arrd.1987.135.2.378
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Santiago,TV
中科院分区：
文献类型：
--
作者：
Parisi,RA;Neubauer,JA;Frank,MM;Edelman,NH;Santiago,TV
睡眠时口咽部的通畅取决于主要的舌前肌--颧舌肌的扩张力。我们测量了清醒和睡眠山羊对CO2的呼吸肌、横隔肌和颧舌肌的肌电反应，从清醒时(0.85±0.087)分/分/毫米汞柱下降到非快速眼动睡眠(0.69±0.069)分再到快速眼动睡眠时(0.57±0.078)分/分/毫米汞柱(与清醒时相比，P<0.005)。在PETCO2为55 mm Hg时，ΔEMGdi/ΔPETCO2和EMGdi从清醒到非快速眼动时下降最小，而快速眼动睡眠期PETCO2为55 mm Hg时EMGdi显著下降(p<；0.025与非快速眼动时相比)。吸气性EMGgg仅高于PCO2阈值，两种睡眠状态的ΔEMGgg/ΔPETCO2均低于清醒状态(P=0.10)。在任何二氧化碳分压下，当眼球快速运动时，吸气EMGgg在REM睡眠中受到明显抑制(时相REM)。我们的结论是，在低二氧化碳分压时和在REM相睡眠期间的任何二氧化碳分压下，颧舌肌相对于横隔肌都有不成比例的抑制。这种不平衡可能使上呼吸道在睡眠期间容易发生吸气阻塞。
Oropharyngeal patency during sleep is dependent on the dilating force of the genioglossus, the main tongue protrusor muscle. We measured the ventilatory , diaphragmatic (EMGdi), and genioglossal (EMGgg) electromyographic responses to CO2in awake and sleeping goats; decreased from awake (0.85 ± 0.087 L/min/mm Hg) to NREM sleep (0.69 ± 0.069) to REM sleep (0.57 ± 0.078, p < 0.005 versus awake). There were minimal decreases in ΔEMGdi/ΔPETCO2and EMGdi at a PETCO2of 55 mm Hg from awake to NREM, but a significant decrease in EMGdi at a PETCO2of 55 mm Hg during REM sleep (p < 0.025 versus NREM). Inspiratory EMGgg was only present above a PCO2threshold, which was similar for each state (49.3 ± 2.3 mm Hg PETCO2awake, 48.8 ± 2.4 during NREM, 49.5 ± 2.5 during REM), and ΔEMGgg/ΔPETCO2tended to be less during both sleep states compared with that while awake (p = 0.10 ). At any PCO2, inspiratory EMGgg was markedly inhibited during REM sleep when rapid eye movements were present (phasic REM). We conclude that there is disproportionate inhibition of the genioglossus relative to the diaphragm at low CO2tensions and at any PCO2during phasic REM sleep. This imbalance may predispose the upper airway to inspiratory occlusion during sleep.