Interferon-γ induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells
Interferon-γ induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells
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DOI：
10.1111/j.1600-0625.2010.01147.x
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发表时间：
2010-10-01
影响因子：
3.6
通讯作者：
Steinhoff, Martin
中科院分区：
文献类型：
--
作者：
Feld, Micha;Shpacovitch, Victoria M.;Steinhoff, Martin
Interleukin-31 (IL-31), a recently discovered cytokine derived from T helper cells, is involved in chronic dermatitis and pruritus. This study demonstrates for the first time that the IL-31 receptor complex for IL-31 is substantially upregulated in human dermal microvascular endothelial cells after stimulation with interferon-gamma (IFN-gamma). Activation of the IL-31 receptor complex results in the induction of the intracellular ERK1/2 signaling pathway and downregulation of IFN-gamma-induced monokine induced by IFN-gamma expression. Inhibitor studies revealed that the IFN-gamma-induced IL-31RA upregulation is processed via JNK and PI3 kinase activation. In sum, our study points toward an interaction between the T(H)1-derived cytokine IFN-gamma and the T(H)2-derived cytokine IL-31 on endothelial cells.
