Manganese enhanced MRI (MEMRI): neurophysiological applications.
Manganese enhanced MRI (MEMRI): neurophysiological applications.
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DOI：
10.1515/rns.2011.048
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发表时间：
2011
影响因子：
4.1
通讯作者：
Pautler RG
中科院分区：
文献类型：
--
作者：
Inoue T;Majid T;Pautler RG
锰离子(Mn2+)是一种钙离子类似物，可通过电压门控钙通道进入神经元和其他兴奋性细胞。Mn2+也是一种顺磁性物质，它缩短了积累了Mn2+的组织的自旋-晶格弛豫时间常数(T1)，导致了正对比度增强。大约20年前，人们首次研究了作为磁共振成像(MRI)造影剂的Mn2+，以评估这种金属在大鼠体内的毒性。20世纪90年代末，Alan Koretsky和他的同事率先使用了锰增强磁共振成像(MEMRI)来研究大脑活动、轨迹追踪和增强解剖细节。本文综述了MEMRI在动物模型脑活动监测、活体神经束示踪以及利用MEMRI评估体内轴突转运率等方面的方法和应用。
Manganese ion (Mn2+) is a calcium (Ca2+) analog that can enter neurons and other excitable cells through voltage gated Ca2+ channels. Mn2+ is also a paramagnetic that shortens the spin-lattice relaxation time constant (T1) of tissues where it has accumulated, resulting in positive contrast enhancement. Mn2+ was first investigated as a magnetic resonance imaging (MRI) contrast agent approximately 20 years ago to assess the toxicity of the metal in rats. In the late 1990s, Alan Koretsky and colleagues pioneered the use of manganese enhanced MRI (MEMRI) towards studying brain activity, tract tracing and enhancing anatomical detail. This review will describe the methodologies and applications of MEMRI in the following areas: monitoring brain activity in animal models, in vivo neuronal tract tracing and using MEMRI to assess in vivo axonal transport rates.