PRIMARY STRUCTURE OF ELECTROPHORUS-ELECTRICUS SODIUM-CHANNEL DEDUCED FROM CDNA SEQUENCE
PRIMARY STRUCTURE OF ELECTROPHORUS-ELECTRICUS SODIUM-CHANNEL DEDUCED FROM CDNA SEQUENCE
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DOI：
10.1038/312121a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
NUMA, S
中科院分区：
文献类型：
--
作者：
NODA, M;SHIMIZU, S;NUMA, S
克隆了E. electricus electroplax Na通道的研究表明，该蛋白由1820个氨基酸残基组成，具有4个重复的同源单元，它们可能以假对称的方式跨膜取向。每个同源单元包含具有成簇的带正电荷的残基的独特区段，其可能涉及门控结构，可能与成簇在别处的带负电荷的残基结合。
Cloning and sequence analysis of cDNA for the E. electricus electroplax Na channel indicate that this protein, consisting of 1820 amino acid residues, exhibits 4 repeated homology units, which are presumably oriented in a pseudosymmetric fashion across the membrane. Each homology unit contains a unique segment with clustered positively charged residues, which may be involved in the gating structure, possibly in conjunction with negatively charged residues clustered elsewhere.