Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder.
Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder.
复制标题
肠道微生物群的改变：治疗自闭症谱系障碍的新策略
DOI：
10.3389/fcell.2022.792490
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发表时间：
2022
影响因子：
5.5
通讯作者：
Fan X
中科院分区：
文献类型：
--
作者：
Liu J;Gao Z;Liu C;Liu T;Gao J;Cai Y;Fan X
Autism spectrum disorder (ASD) is defined as a complex heterogeneous disorder and characterized by stereotyped behavior and deficits in communication and social interactions. The emerging microbial knowledge has pointed to a potential link between gut microbiota dysbiosis and ASD. Evidence from animal and human studies showed that shifts in composition and activity of the gut microbiota may causally contribute to the etiopathogenesis of core symptoms in the ASD individuals with gastrointestinal tract disturbances and act on microbiota-gut-brain. In this review, we summarized the characterized gut bacterial composition of ASD and the involvement of gut microbiota and their metabolites in the onset and progression of ASD; the possible underlying mechanisms are also highlighted. Given this correlation, we also provide an overview of the microbial-based therapeutic interventions such as probiotics, antibiotics, fecal microbiota transplantation therapy, and dietary interventions and address their potential benefits on behavioral symptoms of ASD. The precise contribution of altering gut microbiome to treating core symptoms in the ASD needs to be further clarified. It seemed to open up promising avenues to develop microbial-based therapies in ASD.
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影响因子：
15.5
作者：
Bermudez-Martin P;Becker JAJ;Caramello N;Fernandez SP;Costa-Campos R;Canaguier J;Barbosa S;Martinez-Gili L;Myridakis A;Dumas ME;Bruneau A;Cherbuy C;Langella P;Callebert J;Launay JM;Chabry J;Barik J;Le Merrer J;Glaichenhaus N;Davidovic L
通讯作者：
Davidovic L
自闭症儿童的胃肠道菌群和胃肠道状态 - 与典型儿童相关，并与自闭症的严重程度相关。
影响因子：
2.4
作者：
Adams JB;Johansen LJ;Powell LD;Quig D;Rubin RA
通讯作者：
Rubin RA
影响因子：
1.9
作者：
Arnold, L. Eugene;Luna, Ruth Ann;Savidge, Tor
通讯作者：
Savidge, Tor
影响因子：
5.2
作者：
Coretti, Lorena;Paparo, Lorela;Lembo, Francesca
通讯作者：
Lembo, Francesca
影响因子：
5.3
作者：
Cast, Thomas P.;Boesch, Daniel J.;Chanda, Soham
通讯作者：
Chanda, Soham