Comparative effects of alcohol and marijuana on mood, memory, and performance
Comparative effects of alcohol and marijuana on mood, memory, and performance
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DOI：
10.1016/s0091-3057(96)00456-x
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发表时间：
1997-09-01
影响因子：
3.6
通讯作者：
Stitzer, ML
中科院分区：
文献类型：
--
作者：
Heishman, SJ;Arasteh, K;Stitzer, ML
这项研究比较了主观和行为的影响档案的酒精和吸食大麻的技术，控制喷吸和吸入参数。有中度酒精和大麻使用史的男性志愿者（n = 5）在七个单独的阶段中在双盲条件下随机顺序给予三剂酒精（0.25，0.5或1.0 g/kg），三剂大麻[4，8或16喷3.55% Delta（9）-四氢大麻酚（THC）]和安慰剂。血液酒精浓度（10-90 mg/dl）和THC水平（63-188 ng/ml）表明活性药物以剂量依赖性方式递送至受试者。酒精和大麻在药物作用的主观测量中产生了剂量相关的变化。高剂量的酒精和大麻对感知损害的评级是相同的。两种药物在数字符号替代和单词回忆测试中产生了相当的损害，但在时间感知和反应时间测试中没有影响。酒精，而不是大麻，在数字识别测试中轻微受损。这些数据是有用的，了解酒精和大麻在交付剂量和主观和行为影响之间的关系所产生的相对性能损害。(C)1997年爱思唯尔科学公司
This study compared subjective and behavioral effect profiles of alcohol and smoked marijuana using technology that controlled puffing and inhalation parameters. Male volunteers (n = 5) with histories of moderate alcohol and marijuana use were administered three doses of alcohol (0.25, 0.5, or 1.0 g/kg), three doses of marijuana [4, 8, or 16 puffs of 3.55% Delta(9)-tetrahydrocannabinol (THC)], and placebo in random order under double blind conditions in seven separate sessions. Blood alcohol concentration (10-90 mg/dl) and THC levels (63-188 ng/ml) indicated that active drug was delivered to subjects dose dependently. Alcohol and marijuana produced dose-related changes in subjective measures of drug effect. Ratings of perceived impairment were identical for the high doses of alcohol and marijuana. Both drugs produced comparable impairment in digit-symbol substitution and word recall tests, but had no effect in time perception and reaction time tests. Alcohol, but not marijuana, slightly impaired performance in a number recognition test. These data are useful for understanding the relative performance impairment produced by alcohol and marijuana at the delivered doses and the relationship between their subjective and behavioral effects. (C) 1997 Elsevier Science Inc.