Exosomal microRNAs: potential targets for the prevention and treatment of diabetic cardiomyopathy
Exosomal microRNAs: potential targets for the prevention and treatment of diabetic cardiomyopathy
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外泌体 microRNA：预防和治疗糖尿病心肌病的潜在靶点
DOI：
10.1016/j.jjcc.2021.12.013
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发表时间：
2022
影响因子：
2.5
通讯作者：
Kuihao Chen
中科院分区：
文献类型：
--
作者：
Tao Zhang;Zhe Gao;Kuihao Chen
糖尿病性心肌病（diabetic cardiomyopathy，DCM）是由糖尿病引起的心肌功能不全的一种疾病，已成为世界性的流行病。DCM最初表现为舒张期舒张功能障碍，在没有冠状动脉疾病、瓣膜疾病和其他常规心血管危险因素（如高血压和血脂异常）的情况下，将进展为心力衰竭。然而，DCM的潜在分子机制知之甚少。最近的研究表明，外泌体miRNA与多种DCM危险因素相关，并可能作为潜在的治疗靶点。因此，本文综述了近年来外来体miRNAs在DCM发生发展中的作用，并探讨了潜在的预防和治疗策略。
Diabetic cardiomyopathy (DCM), a condition in which myocardial dysfunction is caused by diabetes mellitus, has become an epidemic disorder in the world. DCM initially presents as diastolic relaxation dysfunction and will progress to heart failure in the absence of coronary artery disease, valvular disease, and other conventional cardiovascular risk factors such as hypertension and dyslipidemia. However, the underlying molecular mechanisms of DCM are poorly understood. Recent studies reveal that exosomal miRNAs are associated with multiple DCM risk factors and may act as potential therapeutic targets. Therefore, this review summarizes the recent advancements to understand the role of exosomal miRNAs in DCM development and explores potential preventative and therapeutic strategies.