Comparisons of Clinical Characteristics and Outcomes in COPD Patients Hospitalized with Community-acquired Pneumonia and Acute Exacerbation
Comparisons of Clinical Characteristics and Outcomes in COPD Patients Hospitalized with Community-acquired Pneumonia and Acute Exacerbation
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DOI：
10.4046/trd.2010.69.1.31
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发表时间：
2010-07-01
影响因子：
2.9
通讯作者：
Kim, Chang Ho
中科院分区：
文献类型：
--
作者：
Jeong, Seung Wook;Lee, Jae Hee;Kim, Chang Ho
背景资料：比较慢性阻塞性肺疾病（COPD）住院患者社区获得性肺炎（CAP-COPD）和急性加重期（AE-COPD）的临床特征和结局的数据非常有限。方法：65例CAP-COPD患者住院80次，82例AE-COPD患者住院111次。对两组患者的基线特征、临床表现、潜在病原菌和临床结局进行回顾性分析和比较。结果：两组患者的COPD相关参数和合并症无显著差异，但CAP-COPD患者中男性比例较高。CAP-COPD患者入院时的症状和实验室检查结果的临床表现明显更严重，与AE-COPD患者相比，CAP-COPD患者的发热和捻发音发生率更高，但喘息较少。S.肺炎支原体和铜绿假单胞菌是两组中最常见的细菌病原体。两组的总住院死亡率无差异，CAP-COPD患者的平均住院时间显著长于AE-COPD患者（分别为15.3和9.8天，p
Background: Data comparing the clinical characteristics and outcomes in chronic obstructive pulmonary disease (COPD) patients hospitalized with community-acquired pneumonia (CAP-COPD) and acute exacerbation (AE-COPD) are very limited.Methods: Eighty episodes of hospitalization in 65 CAP-COPD patients, and 111 episodes of hospitalization in 82 AE-COPD patients were included in this study. The baseline characteristics, clinical presentations, potential bacterial pathogens and clinical outcomes in these patients were retrospectively reviewed and compared.Results: No significant differences were found between the two groups in parameters related to COPD and co-morbidities, except a higher rate of male among CAP-COPD patients. Clinical presentations by symptoms and laboratory findings on admission were significantly more severe in CAP-COPD patients, who showed higher rates of fever and crepitation, but less wheezing than AE-COPD patients. S. pneumoniae and P. aeruginosae were the most common bacterial pathogens in both groups. With no difference in the overall hospital mortality between both groups, the mean length of hospital stay was significantly longer in the CAP-COPD patients than in AE-COPD patients (15.3 vs. 9.8 days, respectively, p