A core–shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy
A core–shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy
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通过原位替代策略消耗谷胱甘肽的核壳液态金属铜纳米粒子用于化学动力学、微波动力学和微波热疗法的肿瘤联合治疗
DOI：
10.1039/d2bm00435f
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发表时间：
2022
影响因子：
6.6
通讯作者：
Xianwei Meng
中科院分区：
文献类型：
--
作者：
Yongnian Yu;Qiong Wu;Meng Niu;Li Gou;Longfei Tan;Changhui Fu;Xiangling Ren;Jun Ren;Yongfa Zheng;Xianwei Meng
高含量谷胱甘肽（GSH）的存在为肿瘤细胞提供了有效的保护屏障，这无疑是基于活性氧（ROS）的治疗的巨大障碍。幸运的是，二价铜（Cu 2+）不仅可以消耗GSH，破坏GSH的保护机制，而且还可以被还原为具有优异的类Fenton反应活性的Cu+。因此，利用液态金属的性质，我们通过原位置换反应引入了三种不同价态的Cu。获得了稳定的核壳型液态金属基Cu贮池。它可以有效地消耗细胞内的GSH，同时通过芬顿样反应产生·OH，进一步提高化学动力学治疗（CDT）的效果。在微波照射下，它还能够产生大量的ROS，促进肿瘤治疗。此外，离子液体的负载使LZC@IL纳米粒子具有一定的微波加热性能，能够增强微波热疗（MWTT）。结合CDT、微波动力疗法（MDT）和MWTT，LZC@IL具有良好的肿瘤消除效果。本工作为液态金属的应用和肿瘤的联合治疗提供了新的思路，具有潜在的应用价值。
The presence of high content glutathione (GSH) provides an effective protective shield for tumor cells, which undoubtedly is a huge impediment to reactive oxygen species (ROS)-based treatment. Fortunately, divalent copper (Cu2+) can not only consume GSH, destroying the protection mechanism of GSH, but also can be reduced to Cu+ with excellent Fenton-like reaction activity. Hence, capitalizing on the properties of liquid metals, we introduced Cu with three different valances via an in situ replacement reaction. A stable core-shell liquid-metal based Cu storage pool was obtained. It can effectively deplete GSH within the cells, and simultaneously produce ·OH through a Fenton-like reaction, further improving the effect of chemodynamic therapy (CDT). Under microwave irradiation, it is also capable of producing a large amount of ROS to promote tumor treatment. In addition, the loading of ionic liquid endows LZC@IL nanoparticles with certain microwave heating performance, which is able to augment microwave thermal therapy (MWTT). With the combination of CDT, microwave dynamic therapy (MDT) and MWTT, LZC@IL has an excellent effect on tumor elimination. This work offers a new idea for the application of liquid metals and the combined treatment of tumors, which has potential application value.