The Use of Maximum Length Sequences to Obtain Brainstem Auditory Evoked Responses at Rapid Rates of Stimulation.
The Use of Maximum Length Sequences to Obtain Brainstem Auditory Evoked Responses at Rapid Rates of Stimulation.
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DOI：
10.1044/1059-0889.0303.16
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发表时间：
1994-11
影响因子：
1.8
通讯作者：
R. Burkard
中科院分区：
文献类型：
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作者：
R. Burkard
使用传统的信号平均程序，可以获得诱发反应的最大速率受到反应时间历元的限制。对于人类脑干听觉诱发反应（BAER）对点击刺激，该时间段至少为10 ms，因此刺激的最大速率为100 Hz。使用低频短纯音和/或使用婴儿受试者需要较低的最大刺激速率，其中反应时间段必须延长至20或25 ms。如果刺激之间的时间小于反应持续时间，则顺序刺激的BAER将在时间上重叠，使反应模糊。可能需要使用更高的刺激速率的原因有很多。首先，使用更高的刺激速率可能需要更少的时间来获得可观察到的反应。第二，可以使用非常快的刺激速率来对听觉系统施加压力，以评估潜在受损的听觉神经系统的完整性。例如，更快的刺激速率和成对点击刺激已被用于使BAER对多发性硬化症引起的神经病理学变化更敏感（Jacobson，Murray，& Deppe，1987;罗宾逊& Rudge，1977）。第三，使用更快的速率将允许更完整地描述
Using conventional signal-averaging procedures, the maximum rate at which one can obtain an evoked response is limited by the response time epoch. For a human brainstem auditory evoked response (BAER) to click stimuli, this time epoch is at least 10 ms, and thus the maximum rate of stimulation is 100 Hz. Lower maximum stimulation rates are required for the use of low-frequency tonebursts and/or the use of infant subjects, where the response time epoch must be extended to 20 or 25 ms. If the time between stimuli is less than the duration of the response, then the BAERs to sequential stimuli will overlap temporally, obscuring the response. There are a number of reasons why it might be desirable to use higher rates of stimulation. First, it might require less time to obtain an observable response using higher rates of stimulation. Second, very rapid rates of stimulation might be used to stress the auditory system to assess the integrity of a potentially compromised auditory nervous system. For example, faster rates of stimulation, and pairedclick stimuli, have been used to make the BAER more sensitive to neuropathologic changes resulting from multiple sclerosis (Jacobson, Murray, & Deppe, 1987; Robinson & Rudge, 1977). Third, the use of faster rates would allow a more complete description of