Sjogren's syndrome at the crossroad of polyautoimmunity
Sjogren's syndrome at the crossroad of polyautoimmunity
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DOI：
10.1016/j.jaut.2012.05.008
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发表时间：
2012-09-01
影响因子：
12.8
通讯作者：
Anaya, Juan-Manuel
中科院分区：
文献类型：
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作者：
Amador-Patarroyo, Manuel J.;Guillermo Arbelaez, Juan;Anaya, Juan-Manuel
自身免疫性疾病的共存（即，在一项涉及410例患者的横断面研究中，对干燥综合征（SS）中的多自身免疫性（多自身免疫性）进行了研究。Logistic回归分析和Rogers和Tanimoto指数分别用于评估危险因素和聚类。134例（32.6%）患者存在多种自身免疫。最常见和最接近的共存疾病是自身免疫性甲状腺疾病（21.5%），类风湿性关节炎（8.3%），系统性红斑狼疮（7.6%），炎症性肠病（0.7%），共同构成一个集群组。多发性自身免疫综合征35例（8.5%）。除病程外，习惯性吸烟和自然流产史也是发生多发性自身免疫的危险因素。这项研究揭示了多发性自身免疫性硬化症的高患病率，其相关的危险因素和分组模式，这样的条件。这些结果可能有助于确定合理的方法来研究自身免疫性疾病的共同机制。(C)2012爱思唯尔有限公司保留所有权利。
The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjogren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases. (C) 2012 Elsevier Ltd. All rights reserved.