The Role of Neurotrophins in Major Depressive Disorder.
The Role of Neurotrophins in Major Depressive Disorder.
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DOI：
10.2478/s13380-013-0103-8
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发表时间：
2013-03-01
影响因子：
2.1
通讯作者：
Salton SR
中科院分区：
文献类型：
--
作者：
Jiang C;Salton SR
神经营养素和其他生长因子已被认为是抑郁行为的关键调节剂。对这一模型的支持基于对基因敲除和转基因小鼠模型的分析、人类遗传学研究以及对受抑郁行为和/或抗抑郁药物调节的基因产物的筛选。例如，由于 proBDNF 中单核苷酸多态性 (SNP) 编码的 Val-Met 取代会影响处理和分类，因此即使脑源性神经营养因子 (BDNF) 调节分泌发生细微变化，也会影响行为和认知。生长因子表达的改变会导致神经发生的变化以及神经元细胞结构的结构变化，包括对海马体、伏核和前额皮质的树突长度和棘密度的影响。这些变化有可能影响中枢神经系统突触的可塑性和稳定性，以及调节行为的复杂大脑回路。在这里，我们回顾了神经营养素在抑郁行为调节中所起的作用，以及它们调节的下游信号传导目标，这些目标可能介导这些行为促抑郁和抗抑郁作用。
Neurotrophins and other growth factors have been advanced as critical modulators of depressive behavior. Support for this model is based on analyses of knockout and transgenic mouse models, human genetic studies, and screens for gene products that are regulated by depressive behavior and/or antidepressants. Even subtle alteration in the regulated secretion of brain-derived neurotrophic factor (BDNF), for example, due to a single nucleotide polymorphism (SNP)-encoded Val-Met substitution in proBDNF that affects processing and sorting, impacts behavior and cognition. Alterations in growth factor expression result in changes in neurogenesis as well as structural changes in neuronal cytoarchitecture, including effects on dendritic length and spine density, in the hippocampus, nucleus accumbens, and prefrontal cortex. These changes have the potential to impact the plasticity and stability of synapses in the CNS, and the complex brain circuitry that regulates behavior. Here we review the role that neurotrophins play in the modulation of depressive behavior, and the downstream signaling targets they regulate that potentially mediate these behavioral pro-depressant and antidepressant effects.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
DOI：
10.1523/jneurosci.3145-08.2008
发表时间：
2008-09-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bozdagi O;Rich E;Tronel S;Sadahiro M;Patterson K;Shapiro ML;Alberini CM;Huntley GW;Salton SR
通讯作者：
Salton SR
影响因子：
4.1
作者：
Budni, Josiane;Lobato, Kelly R.;Rodrigues, Ana Lucia S.
通讯作者：
Rodrigues, Ana Lucia S.
影响因子：
3.1
作者：
Alme MN;Wibrand K;Dagestad G;Bramham CR
通讯作者：
Bramham CR
DOI：
10.1073/pnas.0902833106
发表时间：
2009-09-22
影响因子：
11.1
作者：
Chiaruttini, C.;Vicario, A.;Tongiorgi, E.
通讯作者：
Tongiorgi, E.