USE OF JOINT TOXIC RESPONSE TO DEFINE THE PRIMARY-MODE OF TOXIC ACTION FOR DIVERSE INDUSTRIAL ORGANIC-CHEMICALS
USE OF JOINT TOXIC RESPONSE TO DEFINE THE PRIMARY-MODE OF TOXIC ACTION FOR DIVERSE INDUSTRIAL ORGANIC-CHEMICALS
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DOI：
10.1002/etc.5620140920
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发表时间：
1995-09-01
影响因子：
4.1
通讯作者：
HOGLUND, MD
中科院分区：
文献类型：
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作者：
BRODERIUS, SJ;KAHL, MD;HOGLUND, MD
了解多种毒物如何共同作用的一个重要方面包括确定感兴趣的化学物质的主要毒性作用模式。我们已经探索了使用幼年黑头鲦鱼和主要二元化学混合物进行96小时急性毒性试验，以确定各种工业有机化学品的主要急性毒性作用模式。我们的研究主要考虑了两种非交互联合作用的特殊情况，即浓度（简单相似）和响应（独立）相加。用等波图图解了二元混合物不同形式的联合毒性。指定为特定作用模式参考毒物的是1-辛醇、苯酚和2,4-二硝基苯酚。从二元等波图中可以观察到，在整个混合比例范围内，具有与参考毒物相似的初级毒性模式的化学品将与参考毒物表现出浓度-添加型的联合作用。具有非常陡峭的浓度-响应曲线的不同化学物质通常表现出低于浓度添加剂的相互作用，但始终表现出比响应-添加模型预测的更大的联合毒性。在我们的实验中，并不常见到指示相互作用毒性的超过浓度的添加剂和复杂的等孔。
An important aspect of understanding how multiple toxicants jointly act involves defining the primary mode of toxic action for the chemicals of interest. We have explored the use of 96-h acute toxicity tests with juvenile fathead minnows and primarily binary chemical mixtures to define the primary acute mode of toxic action for diverse industrial organic chemicals. Our investigation mainly considered the two special cases of noninteractive joint action known as concentration (simple similar) and response (independent) addition. The different forms of joint toxicity with binary mixtures were graphically illustrated by isobole diagrams. Designated as the mode of action-specific reference toxicants were 1-octanol, phenol, and 2,4-dinitrophenol. It was observed from binary isobole diagrams that a chemical with a similar primary mode of toxic action to that of a reference toxicant would display a concentration-addition type of joint action with the reference toxicant over the entire mixture ratio range. Dissimilar chemicals with very steep concentration-response curves generally showed an interaction that was less-than-concentration additive, but consistently demonstrated a joint toxicity that was greater than predicted by the response-addition model. The more-than-concentration additive and complex isoboles that are indicative of interactive toxicity were not commonly observed in our experiments.