EFFECT OF HYALURONIC-ACID CHONDROITIN SULFATE ON HEALING OF FULL-THICKNESS TENDON LACERATIONS IN RABBITS
EFFECT OF HYALURONIC-ACID CHONDROITIN SULFATE ON HEALING OF FULL-THICKNESS TENDON LACERATIONS IN RABBITS
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DOI：
10.1002/jor.1100070508
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发表时间：
1989-09-01
影响因子：
2.8
通讯作者：
NUNLEY, JA
中科院分区：
文献类型：
--
作者：
MEYERS, SA;SEABER, AV;NUNLEY, JA
Viscoat是一种高分子量、高纯度的透明质酸（HA）和硫酸软骨素（CS）复合物，在全层撕裂和手术修复后，在兔跖肌腱周围滴注Viscoat。固定3周后，Viscoat处理肌腱和对照肌腱之间的愈合肌腱的粘附强度或拉伸强度没有显著差异。这与之前的研究相矛盾，之前的研究表明透明质酸可以减少术后肌腱粘连。进一步的研究检查肌腱粘连后，不太严重的肌腱损伤程度，并使用直接，定量测量技术是必要的，以证明是否HA对肌腱愈合的有益影响。
Viscoat, a high-molecular-weight, highly purified hyaluronic acid (HA) and chondroitin sulfate (CS) compound, was instilled around rabbit plantaris tendon following full-thickness laceration and surgical repair. After 3 weeks of immbolization, no significant difference in adhesion strength or tensile strength of the healing tendons existed bewteen Viscoat-treated tendons and controls. This contradicts previous studies which suggest that hyaluronic acid reduces postoperative tendon adhesions. Further studies examining tendon adhesions after less severe degrees of tendon injury and using direct, quantitative measurement techniques are warranted to demonstrate whether HA has a beneficial effect on tendon healing.