Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression
Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression
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DOI：
10.1016/s0925-4927(01)00086-5
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发表时间：
2001-07-01
影响因子：
2.3
通讯作者：
Tunca, Z
中科院分区：
文献类型：
--
作者：
Alptekin, K;Degirmenci, B;Tunca, Z
本研究的目的是确认以前的结果脑成像研究强迫症（OCD）的样本中的土耳其患者，作为一个跨文化的研究。对9例无抑郁症的无药物强迫症患者和6例对照者进行了Tc-99 mHMPAO脑灌注SPECT显像。患者的汉密尔顿抑郁量表评分< 16分。采用耶鲁-布朗强迫症评定量表（YBOCS）评定强迫症状的严重程度。局部脑血流定量评价显示，与对照组相比，强迫症患者的右侧丘脑，左侧额颞叶皮质和双侧眶额皮质表现出显着的高灌注。YBOCS评分与这些区域的局部脑血流灌注过度没有任何相关性。这项跨文化研究的结果可能支持土耳其患者样本中强迫症的眶额和丘脑功能障碍。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
The aim of this study was to confirm prior results of brain-imaging studies on obsessive-compulsive disorder (OCD) in a sample of Turkish patients, as a cross-cultural study. Tc-99m HMPAO brain perfusion SPECT imaging was performed in nine drug-free OCD patients without depression and six controls. The patients' Hamilton Depression Rating Scale scores were < 16. The severity of obsessive-compulsive symptoms was rated with the Yale-Brown Obsessive-Compulsive Rating Scale (YBOCS). Quantitative evaluation of regional cerebral blood flow revealed that right thalamus, left frontotemporal cortex and bilateral orbitofrontal cortex showed significant hyperperfusion in patients with OCD compared with controls. YBOCS scores did not show any correlation with hyperperfusion in regional cerebral blood flow in these areas. Results of this cross-cultural study may support orbitofrontal and thalamic dysfunction in OCD in a sample of Turkish patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.