Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry.
Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry.
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DOI：
10.1007/s10549-016-3984-8
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发表时间：
2016-11
影响因子：
3.8
通讯作者：
Tokuda, Yutaka
中科院分区：
文献类型：
--
作者：
Kataoka, Akemi;Iwamoto, Takayuki;Tokunaga, Eriko;Tomotaki, Ai;Kumamaru, Hiraku;Miyata, Hiroaki;Niikura, Naoki;Kawai, Masaaki;Anan, Keisei;Hayashi, Naoki;Masuda, Shinobu;Tsugawa, Koichiro;Aogi, Kenjiro;Ishida, Takanori;Masuoka, Hideji;Iijima, Kotaro;Kinoshita, Takayuki;Nakamura, Seigo;Tokuda, Yutaka
本研究的目的是探讨在调整已知的临床病理学预后因素后，日本乳腺癌登记处的患者中，年轻的乳腺癌发病年龄是否是一个独立的预后因素。在2004年至2006年期间登记并在5年随访预后后接受调查的53，670名患者中，对获得预后数据的25，898名乳腺癌患者（48.3%）进行了检查。比较了青年（YA; <35岁）、中年（MA; 35-50岁）和老年（OA; >50岁）患者的临床病理因素。研究了5年无病生存率（DFS）和总生存率（OS）。与MA和OA患者相比，YA患者与晚期TNM分期和侵袭性特征（例如，人表皮生长因子受体2（HER 2）阳性或雌激素受体（ER）阴性乳腺癌）相关（P < 0.001）。YA、MA和OA患者的5年DFS和OS率分别为79.4%和90.8%、88.5%和95.0%以及87.8%和91.6%。从多变量回归分析，发病时年龄小被证实是DFS（风险比1.73，95%置信区间1.42-2.10; P < 0.001）和OS（风险比1.58，95%置信区间1.16-2.15; P = 0.004）的独立预后因素。发病年龄小是乳腺癌独立的负性预后因素。需要进一步的研究来为YA乳腺癌患者开发新的治疗策略。本文的在线版本（doi：10.1007/s10549-016-3984-8）包含补充材料，可供授权用户使用。
The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 %), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35–50 years), and older adult (OA; >50 years) patients. Five-year disease-free survival (DFS) and overall survival (OS) rates were studied. YA patients were associated with an advanced TNM stage and aggressive characteristics (e.g. human epidermal growth factor receptor 2 (HER2)-positive or oestrogen receptor (ER)-negative breast cancers) compared to MA and OA patients (P < 0.001). The 5-year DFS and OS rates were 79.4 % and 90.8, 88.5 and 95.0 %, and 87.8 % and 91.6 % for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS (hazard ratio 1.73, 95 % confidence interval 1.42–2.10; P < 0.001) and OS (hazard ratio 1.58, 95 % confidence interval 1.16–2.15; P = 0.004). Young age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients. The online version of this article (doi:10.1007/s10549-016-3984-8) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/j.jamcollsurg.2008.12.001
发表时间：
2009-03
影响因子：
5.2
作者：
Gnerlich, Jennifer L.;Deshpande, Anjali D.;Jeffe, Donna B.;Sweet, Allison;White, Nick;Margenthaler, Julie A.
通讯作者：
Margenthaler, Julie A.
影响因子：
11.5
作者：
Azim, Hatem A., Jr.;Michiels, Stefan;Loi, Sherene
通讯作者：
Loi, Sherene
影响因子：
168.9
作者：
DELAROCHEFORDIERE, A;ASSELAIN, B;FOURQUET, A
通讯作者：
FOURQUET, A
DOI：
10.1007/s12282-015-0644-5
发表时间：
2016-01
期刊：
Breast cancer (Tokyo, Japan)
影响因子：
--
作者：
Kinoshita T;Fukui N;Anan K;Iwamoto T;Niikura N;Kawai M;Hayashi N;Tsugawa K;Aogi K;Ishida T;Masuoka H;Masuda S;Iijima K;Nakamura S;Tokuda Y
通讯作者：
Tokuda Y
影响因子：
50.5
作者：
Cancello, G.;Maisonneuve, P.;Colleoni, M.
通讯作者：
Colleoni, M.