Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
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DOI：
10.1002/mds.20141
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发表时间：
2004-10-01
影响因子：
8.6
通讯作者：
Reichmann, H
中科院分区：
文献类型：
--
作者：
Sommer, U;Hummel, T;Reichmann, H
嗅觉丧失是帕金森病 (PD) 的早期症状之一。我们研究了“特发性”嗅觉功能障碍是否可能与黑质变性的迹象有关。嗅觉测试与黑质经颅超声检查和单光子发射计算机断层扫描（SPECT）成像相结合。三十名被诊断患有特发性嗅觉丧失的患者参与了研究。其中 11 名患者在经颅超声检查中表现出 SN 回声增强。在这 11 名患者中，有 10 名患者使用 I-123-FP-CIT 进行了 SPECT 扫描。 5 名患者的基底神经节中位摄取率呈病理性，2 名患者表现出边缘结果，3 名患者结果正常。考虑到患有特发性嗅觉功能障碍的患者，无创经颅超声检查似乎有助于识别有患帕金森病风险的患者。需要进行纵向随访研究来估计基底神经节多巴胺能细胞丢失的患者未来发展为帕金森病的比例。 (C) 2004 年运动障碍协会。
Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether "idiopathic" olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with I-123-FP-CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow-up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future. (C) 2004 Movement Disorder Society.