Quantitative analysis of tumor vascularity in benign and malignant solid thyroid nodules
Quantitative analysis of tumor vascularity in benign and malignant solid thyroid nodules
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DOI：
10.7863/jum.2007.26.6.837
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发表时间：
2007-06-01
影响因子：
2.3
通讯作者：
Fleischer, Arthur C.
中科院分区：
文献类型：
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作者：
Lyshchik, Andrej;Moses, Ryan;Fleischer, Arthur C.
Objective.本研究的目的是以肿瘤组织学评价为参考标准，分析能量多普勒超声对肿瘤血管定量分析在鉴别甲状腺实性结节良恶性方面的准确性。方法.在我们的研究中，纳入了56名连续患者（平均年龄+/- SD，53.1 +/- 11.6岁; 12名男性和44名女性）的86个甲状腺实体瘤（46个恶性和40个良性），这些患者接受了手术治疗，对所有肿瘤的结节血管分布模式进行了视觉和定性分析。能量多普勒超声图的量化采用标准化和加权血管指数（维斯）。采用单因素分析评价甲状腺癌超声诊断标准的准确性。结果在良性甲状腺肿瘤中，随着肿瘤体积的增大，结节内血管化水平显著增加（P
Objective. The purpose of our study was to analyze the accuracy of quantitative analysis of tumor vascularity on power Doppler sonograms in differentiating malignant and benign solid thyroid nodules using tumor histologic evaluation as the reference standard. Methods. Eighty-six solid thyroid tumors (46 malignant and 40 benign) in 56 consecutive patients (mean age +/- SD, 53.1 +/- 11.6 years; 12 male and 44 female) referred for the surgical treatment were included in our study Visual and qualitative analysis of patterns of nodule vascularity was performed for all tumors. Quantification of the power Doppler sonograms was per-formed with normalized and weighted vascular indices (VIs). The accuracy of sonographic criteria for thyroid cancer was evaluated with univariate analysis. Results. Among benign thyroid tumors, there was a statistically significant increase in the levels of intranodular vascularization with an increase in tumor size (P