Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways
Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways
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DOI：
10.1016/j.neuron.2018.08.002
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发表时间：
2018-09-19
期刊：
影响因子：
16.2
通讯作者：
Kimura, Minoru
中科院分区：
文献类型：
--
作者：
Nonomura, Satoshi;Nishizawa, Kayo;Kimura, Minoru
基底神经节在由奖赏和惩罚引导的适应行为中起着关键作用。然而，尽管积累了知识，很少有研究测试基底神经节中的异质信号是如何组织和协调目标导向行为的。在这项研究中，我们研究了大鼠进行杠杆推/拉任务的概率奖励的基底神经节的直接和间接途径的神经元信号。在背内侧纹状体，我们发现，光遗传学和电生理识别的直接通路神经元编码奖励结果，而间接通路神经元编码无奖励结果和下一个动作选择。结果编码与所选择的行动相关。在支持的通路特异性神经元编码，光激活诱导的偏见重复选择相同的行动在直接途径，但开关选择在间接途径。我们的数据揭示了通过基底神经节回路监测和更新目标导向行为的行动选择的机制。
The basal ganglia play key roles in adaptive behaviors guided by reward and punishment. However, despite accumulating knowledge, few studies have tested how heterogeneous signals in the basal ganglia are organized and coordinated for goal-directed behavior. In this study, we investigated neuronal signals of the direct and indirect pathways of the basal ganglia as rats performed a lever push/pull task for a probabilistic reward. In the dorsomedial striatum, we found that optogenetically and electrophysiologically identified direct pathway neurons encoded reward outcomes, whereas indirect pathway neurons encoded no-reward outcome and next-action selection. Outcome coding occurred in association with the chosen action. In support of pathway-specific neuronal coding, light activation induced a bias on repeat selection of the same action in the direct pathway, but on switch selection in the indirect pathway. Our data reveal the mechanisms underlying monitoring and updating of action selection for goal-directed behavior through basal ganglia circuits.