Nestin is highly expressed in advanced-stage melanomas and neurotized nevi
Nestin is highly expressed in advanced-stage melanomas and neurotized nevi
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DOI：
10.3892/or.2013.2287
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发表时间：
2013-04-01
期刊：
影响因子：
4.2
通讯作者：
Kawana, Seiji
中科院分区：
文献类型：
--
作者：
Akiyama, Michiko;Matsuda, Yoko;Kawana, Seiji
巢蛋白是一种VI类中间丝蛋白，最初被描述为神经干细胞/祖细胞标志物。据报道，巢蛋白的表达与各种类型肿瘤的迁移和转移有关。在本研究中，我们研究巢蛋白在恶性黑色素瘤和痣的表达。免疫组化显示，巢蛋白在所有复合痣中均被检测到，但在大多数交界痣中未检测到。Nestin在神经化痣中的表达水平特别高。在黑色素瘤中，巢蛋白在所有T3和T4病例中表达，但只有一半的T2或不太严重的疾病病例中表达。这些结果表明，黑色素瘤中巢蛋白的表达水平与晚期疾病有关。总之，巢蛋白在晚期黑色素瘤组织和神经化痣中表达。巢蛋白可能是黑素细胞肿瘤的重要标志物。巢蛋白表达的调控机制以及巢蛋白靶向治疗恶性黑色素瘤的可能性有待进一步研究。
Nestin, a class VI intermediate filament protein, was originally described as a neural stem cell/progenitor cell marker. Expression of nestin has been reported to be associated with the migration and metastasis of various types of tumor. In the present study, we examined the expression of nestin in malignant melanomas and nevi. Immunohistochemically, nestin was detected in all compound nevi, but not in the majority of junctional nevi. Nestin was expressed at particularly high levels in nevi with neurotization. In melanoma, nestin was expressed in all T3 and T4 cases, but only in half of the cases of T2 or less severe disease. These results indicate that the expression levels of nestin in melanoma are associated with advanced disease. In conclusion, nestin was expressed in advanced melanoma tissues and neurotized nevi. Nestin may be an important marker of melanocytic neoplasms. Further studies are required to elucidate the regulatory mechanisms of nestin expression and to examine the possibility of nestin-targeted therapy for malignant melanomas.