Prevalence, Emergence, and Factors Associated with a Viral Papillomatosis and Carcinomatosis Syndrome in Wild, Reintroduced, and Captive Western Barred Bandicoots (Perameles bougainville)
Prevalence, Emergence, and Factors Associated with a Viral Papillomatosis and Carcinomatosis Syndrome in Wild, Reintroduced, and Captive Western Barred Bandicoots (Perameles bougainville)
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野生、放归和圈养西部斑袋狸（Perameles bougainville）中病毒性乳头状瘤病和癌瘤病综合征的患病率、出现率和相关因素
DOI：
10.1007/s10393-009-0258-5
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发表时间：
2009
期刊：
影响因子：
2.5
通讯作者：
A. O'hara
中科院分区：
文献类型：
--
作者：
L. Woolford;M. Bennett;C. Sims;N. Thomas;J. Friend;P. Nicholls;K. Warren;A. O'hara
曾经广泛分布在澳大利亚西部和南部的西部条纹袋鼠(WBB)的野生种群现在只在西澳大利亚的伯尼尔和多雷群岛上才能找到。目前，在圈养和野生袋鼠中发现的乳头状瘤病和癌症综合症，与感染1型袋鼠乳头状瘤病癌症病毒(BPCV1)有关，阻碍了防止WBB灭绝的保护努力。这项研究调查了西澳大利亚两个岛屿和四个大陆(重新引入和圈养)WBB人群中BPCV1和相关综合征的患病率和分布，以及可能与该综合征易感性相关的因素。BPCV1和该综合征在伯尼尔岛红崖的野生WBB种群中被发现，并在由红崖的全部或部分创始人WBB建立的大陆种群中被发现。BPCV1和该综合征在多雷岛的野生种群中没有发现，在完全由多雷岛的动物建立的大陆种群中也没有发现。研究结果显示，BPCV1和该综合症是通过从赤壁传入受影响的WBB而传播到内地WBB人群的。在多雷岛、伯尼尔岛和跨岛个体之间，对该综合征的易感性没有发现差异。圈养中观察到的病变严重程度和受影响动物的数量比野生种群中观察到的更多。这项研究提供了流行病学证据，支持BPCV1感染与乳头状瘤病和癌病综合征之间的病理和分子联系，并发现年龄增加是这种疾病的另一个危险因素。
Once widespread across western and southern Australia, wild populations of the western barred bandicoot (WBB) are now only found on Bernier and Dorre Islands, Western Australia. Conservation efforts to prevent the extinction of the WBB are presently hampered by a papillomatosis and carcinomatosis syndrome identified in captive and wild bandicoots, associated with infection with the bandicoot papillomatosis carcinomatosis virus type 1 (BPCV1). This study examined the prevalence and distribution of BPCV1 and the associated syndrome in two island and four mainland (reintroduced and captive) WBB populations in Western Australia, and factors that may be associated with susceptibility to this syndrome. BPCV1 and the syndrome were found in the wild WBB population at Red Cliff on Bernier Island, and in mainland populations established from all or a proportion of founder WBBs from Red Cliff. BPCV1 and the syndrome were not found in the wild population on Dorre Island or in the mainland population founded by animals exclusively from Dorre Island. Findings suggested that BPCV1 and the syndrome were disseminated into mainland WBB populations through the introduction of affected WBBs from Red Cliff. No difference in susceptibility to the syndrome was found between Dorre Island, Bernier Island, and island-cross individuals. Severity of lesions and the number of affected animals observed in captivity was greater than that observed in wild populations. This study provided epidemiological evidence to support the pathological and molecular association between BPCV1 infection and the papillomatosis and carcinomatosis syndrome and revealed increasing age as an additional risk factor for this disease.