PREPARATION AND INVIVO STUDIES OF A NEW DRUG DELIVERY SYSTEM - NANOPARTICLES OF ALKYLCYANOACRYLATE
PREPARATION AND INVIVO STUDIES OF A NEW DRUG DELIVERY SYSTEM - NANOPARTICLES OF ALKYLCYANOACRYLATE
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DOI：
10.1007/bf02783760
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发表时间：
1984-01-01
影响因子：
3
通讯作者：
COUVREUR, P
中科院分区：
文献类型：
--
作者：
MAINCENT, P;DEVISSAGUET, JP;COUVREUR, P
以长春花胺为模型药物制备了聚氰丙烯酸己基纳米粒。这些颗粒的平均尺寸为200纳米，吸附了大约435个长春胺。纳米粒子对长春花胺的吸附改变了长春花胺在组织中的分布。与药物水溶液相比，静脉注射后分布体积增加。与药物水溶液相比，口服纳米颗粒后，长春花胺的绝对生物利用度也有所提高。
Polyhexylcyanoacrylate nanoparticles have been prepared with vincamine as the model drug. These particles had an average size of 200 nm and adsorbed approximately 435 of vincamine. The adsorption of vincamine to nanoparticles modified the distribution of vincamine in tissues. After iv injection the distribution volumes were increased in comparison with an aqueous solution of drug. In comparison with an aqueous solution of drug, the absolute bioavailability of vincamine was also increased after an oral administration of nanoparticles.