Facile Synthesis of 1,2,4-Triazoles via a Copper-Catalyzed Tandem Addition-Oxidative Cyclization
Facile Synthesis of 1,2,4-Triazoles via a Copper-Catalyzed Tandem Addition-Oxidative Cyclization
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DOI：
10.1021/ja905056z
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发表时间：
2009-10-28
影响因子：
15
通讯作者：
Nagasawa, Hideko
中科院分区：
文献类型：
--
作者：
Ueda, Satoshi;Nagasawa, Hideko
在空气气氛下，通过铜催化的氧化偶联反应提供了1，2，4-三唑衍生物的简单一步合成。该过程应包括顺序。形成N-C和N-N键的铜催化氧化偶联反应。起始材料和铜催化剂容易获得并且便宜。容许宽范围的官能团以实现化学多样性。
A simple one-step synthesis of 1,2,4-triazole derivatives is provided by a copper-catalyzed oxidative coupling reaction under an atmosphere of air. The process should consist of sequential. N-C and N-N bond-forming copper-catalyzed oxidative coupling reactions. Starting materials and the copper catalyst are readily available and inexpensive. A wide range of functional groups are tolerated to achieve chemical diversity.