Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomas
Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomas
复制标题
伯基特和非伯基特淋巴瘤患者活检和淋巴细胞系中的特征性染色体异常
DOI：
10.1002/ijc.2910170108
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发表时间：
1976
影响因子：
6.4
通讯作者：
G. Klein
中科院分区：
文献类型：
--
作者：
L. Zech;U. Haglund;Kenneth Nilsson;G. Klein
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The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non‐BL sources were studied by chromosome banding techniques. With the exception of the BL‐derived cell lines BJAB, GC‐BJAB, Maku and U‐8691 all biopsies and lines of Burkitt origin contained an extra band at the distal region of the long arm of one chromosome 14. An extra band on chromosome 14 was also found in cells of one non‐BL biopsy, in cells from a lymphosarcoma‐derived cell line and in a longestablished cell line derived from the pleural exudate of a patient with Hodgkin's disease. A distal region at the long arm of one chromosome 8 was missing in all metaphase figures of good technical quality in the same material. The size, morphology and stainability of missing region corresponded fairly well to the extra region at chromosome 14. We therefore suggest that the chromosome 14 marker represents a translocation between chromosomes 8 and 14,t (8q‐; 14q+). The translocation was present neither in lymphocytes of peripheral blood of five Burkitt patients nor in five lymphoblastoid cell lines of non‐BL origin. Trisomy 7 was found in two of the 10 BL biopsies, in two BL‐derived cell lines, in one non‐BL biopsy, in two lymphosarcoma‐derived cell lines and in one cell line derived from a patient with Hodgkin's disease.