Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic marker of ventilator-associated pneumonia.
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic marker of ventilator-associated pneumonia.
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DOI：
10.4187/respcare.01703
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发表时间：
2012-12
期刊：
影响因子：
2.5
通讯作者：
Schnapp LM
中科院分区：
文献类型：
--
作者：
Palazzo SJ;Simpson TA;Simmons JM;Schnapp LM
To determine the utility of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) samples from patients who underwent bronchoscopy for a clinical suspicion of ventilator-associated pneumonia (VAP), to categorize patients as VAP positive and VAP negative, when compared to quantitative culture results of BALF. Observational study conducted on admitted patients in the trauma-surgical, medical-cardiac, burn, and neurosurgical ICUs of Harborview Medical Center between March 2009 and May 2010. BALF and EBC samples were obtained from 45 patients with clinically suspected VAP. Bronchoscopy was performed on the day of clinically suspected VAP. sTREM-1 levels in EBC and BAL fluid were measured using quantikine human TREM-1 immunoassay. VAP was diagnosed by quantitative cultures of BALF. The concentrations of sTREM-1 in BALF and EBC did not correlate with VAP status. sTREM-1 levels did not discriminate VAP positive from VAP negative patients, when compared to quantitative cultures of BALF as the gold standard. Using a cutoff value of 204 pg/mL for BALF sTREM-1 levels resulted in a sensitivity of 79% and a specificity of 23%. A cutoff value of 10 pg/mL for EBC sTREM-1 levels resulted in a sensitivity of 42% and a specificity of 50%. EBC and BALF sTREM-1 levels did not effectively categorize patients as VAP positive or VAP negative when using direct bronchoscopic quantitative culture samples as the comparison standard.
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影响因子：
11.8
作者：
Mayhall CG
通讯作者：
Mayhall CG
影响因子：
15.3
作者：
Gibot, S;Kolopp-Sarda, MN;Béné, MC;Bollaert, PE;Lozniewski, A;Mory, F;Levy, B;Faure, GC
通讯作者：
Faure, GC
影响因子：
4.4
作者：
Knapp, S;Gibot, S;van der Poll, T
通讯作者：
van der Poll, T
DOI：
10.1164/rccm.200212-1449oc
发表时间：
2003-07-15
影响因子：
24.7
作者：
Fartoukh, M;Maître, B;Brun-Buisson, C
通讯作者：
Brun-Buisson, C
影响因子：
38.9
作者：
Luyt, CE;Chastre, J;Fagon, JY
通讯作者：
Fagon, JY