Bilateral medial temporal lobe damage does not affect lexical or grammatical processing: Evidence from amnesic patient HM
Bilateral medial temporal lobe damage does not affect lexical or grammatical processing: Evidence from amnesic patient HM
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DOI：
10.1002/hipo.1049.abs
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Corkin, S
中科院分区：
文献类型：
--
作者：
Kensinger, EA;Ullman, MT;Corkin, S
在迄今为止对全面性遗忘症的语言进行的最广泛的调查中，我们从实验测量中获得了数据，并检查了标准化测试的纵向数据，以确定遗忘症患者H.M.实验结果表明，H.M.在词汇记忆和语法功能测试中，相对于年龄和教育程度相匹配的对照组参与者，从韦氏四个子测验（信息，理解，相似性和词汇）的纵向数据，H.M.在1953年（术前）和2000年之间进行了20次，表明随着时间的推移表现一致，并且没有提供词汇记忆减少的证据。我们的结论是内侧颞叶结构是不是保留和使用已经获得的词汇信息或语法处理的关键。然而，正如先前的研究所证明的那样，它们是获得词汇信息所必需的。在学习新单词方面的严重缺陷。海马2001;11：347-360. (C)2001 Wiley-Liss，Inc.
In the most extensive investigation to date of language in global amnesia, we acquired data from experimental measures and examined longitudinal data from standardized tests, to determine whether language function was preserved in the amnesic patient H.M. The experimental measures indicated that H.M. performed normally on tests of lexical memory and grammatical function, relative to age- and education-matched control participants. Longitudinal data from four Wechsler subtests (information, Comprehension, Similarities, and Vocabulary), that H.M. had taken 20 times between 1953 (preoperatively) and 2000, indicated consistent performance across time, and provided no evidence of a lexical memory decrement. We conclude that medial temporal lobe structures are not critical for retention and use of already acquired lexical information or for grammatical processing. They are, however, required for acquisition of lexical information, as evidenced in previous studies revealing H.M.'s profound impairment at learning new words. Hippocampus 2001;11:347-360. (C) 2001 Wiley-Liss, Inc.