Influence of growth rate and nutrient limitation on susceptibility of Burkholderia cepacia to ciprofloxacin and tobramycin
Influence of growth rate and nutrient limitation on susceptibility of Burkholderia cepacia to ciprofloxacin and tobramycin
复制标题
DOI：
10.1093/jac/40.3.415
复制
发表时间：
1997-09-01
影响因子：
5.2
通讯作者：
Allison, DG
中科院分区：
文献类型：
--
作者：
McKenney, D;Allison, DG
生长速率和氧气供应对环丙沙星和妥布霉素的敏感性和洋葱伯克霍尔德氏菌的细胞表面疏水性的影响进行了评估，在恒化器下生长的细胞铁限制。而敏感性的两种抗生素下降，增加生长速度和氧气补充，但增加缺氧，疏水性下降，增加生长速度和氧气补充，但相对不受影响的缺氧。这些结果强调了生长环境对抗生素敏感性的调节作用，以及在体外密切模拟体内细菌生长的条件下进行抗菌药物敏感性试验的必要性。
The influence of growth rate and oxygen availability on ciprofloxacin and tobramycin sensitivity and cell surface hydrophobicity in Burkholderia cepacia was assessed for cells grown in a chemostat under iron-limitation. Whereas susceptibility to both antibiotics decreased with increasing growth rate and oxygen repletion yet increased under oxygen depletion, hydrophobicity decreased with increasing growth rate and oxygen repletion but was relatively unaffected under oxygen depletion. These results emphasize the modulating effect of the growth environment on antibiotic susceptibility and the need to perform antimicrobial susceptibility tests under conditions which closely mimic, in vitro, bacterial growth in vivo.