Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
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DOI：
10.1194/jlr.r800082-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Zechner, Rudolf
中科院分区：
文献类型：
--
作者：
Kienesberger, Petra C.;Oberer, Monika;Zechner, Rudolf
人类基因组表达9种含有马铃薯糖蛋白样磷脂酶结构域的蛋白质（PNPLA 1 -9）。这个家族的成员共享最初在马铃薯块茎中最丰富的蛋白质patatin中发现的蛋白质结构域。Patatin是一种具有不同于经典脂肪酶的不寻常折叠拓扑结构的脂质水解酶。哺乳动物PNPLA包括对多种底物具有特异性的脂质水解酶，如三酰基甘油、磷脂和视黄醇酯。诱导突变小鼠模型和突变患者的临床表型分析揭示了PNPLA家族的几个成员的生理作用的重要见解。jlr这篇综述旨在总结PNPLA蛋白质的当前知识，并记录其在脂质和能量稳态中的重要性。Kienesberger，P. C.，M. Oberer，A. Lass和R.泽克纳哺乳动物patatin结构域蛋白：一个具有多种生物学功能的脂肪分解活性家族。J. Lipid Res. 2009. S63-S68
The human genome expresses nine patatin-like phospholipase domain containing proteins (PNPLA1-9). Members of this family share a protein domain discovered initially in patatin, the most abundant protein of the potato tuber. Patatin is a lipid hydrolase with an unusual folding topology that differs from classical lipases. Mammalian PNPLAs include lipid hydrolases with specificities for diverse substrates such as triacylglycerols, phospholipids, and retinol esters. Analysis of induced mutant mouse models and the clinical phenotype of patients with mutations revealed important insights into the physiological role of several members of the PNPLA family.jlr This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis.-Kienesberger, P. C., M. Oberer, A. Lass, and R. Zechner. Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J. Lipid Res. 2009. S63-S68.