Molecular epidemiology of respiratory syncytial virus in The Gambia
Molecular epidemiology of respiratory syncytial virus in The Gambia
复制标题
DOI：
10.1017/s0950268896001872
复制
发表时间：
1999-02-01
影响因子：
4.2
通讯作者：
Whittle, H
中科院分区：
文献类型：
--
作者：
Cane, PA;Weber, M;Whittle, H
冈比亚的呼吸道合胞病毒（RSV）感染季节性发生，与雨季有关。本研究检测了1993- 1996年连续四次流行的RSV分离株的遗传变异。附着（G）蛋白基因序列分析表明，分离株与世界其他地区观察到的菌株密切相关。然而，1993年和1994年的许多分离株与此期间在发达国家观察到的其他分离株不同，与1984年在欧洲观察到的分离株更相似。此外，20世纪90年代在英国最常见的基因型在冈比亚没有检测到。
Respiratory syncytial virus (RSV) infection in The Gambia occurs seasonally in association with the rainy season. This study examined the genetic variability of RSV isolates from four consecutive epidemics from 1993-6, Each epidemic was made up of a number of variants which were replaced in subsequent epidemics. Analysis of attachment (G) protein gene sequences showed that isolates were closely related to those observed in the rest of the world. However, many isolates from 1993 and 1994 were unlike other isolates observed in the developed world during this period and were more similar to isolates from 1984 in Europe. In addition, the most commonly observed genotype in the UK in the 1990s was not detected in The Gambia during this period.