Low Handgrip Strength is Associated with Low Bone Mineral Density and Fragility Fractures in Postmenopausal Healthy Korean Women
Low Handgrip Strength is Associated with Low Bone Mineral Density and Fragility Fractures in Postmenopausal Healthy Korean Women
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DOI：
10.3346/jkms.2012.27.7.744
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发表时间：
2012-07-01
影响因子：
4.5
通讯作者：
Cho, Eun-Hee
中科院分区：
文献类型：
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作者：
Kim, Sang Wook;Lee, Hyang Ah;Cho, Eun-Hee
骨质疏松症是绝经后妇女普遍存在的健康问题。骨质疏松性骨折降低了独立性，限制了日常生活活动，并增加了死亡率。流行病学研究表明，低握力是功能限制和残疾以及全因死亡的危险因素。我们调查了337名健康绝经后韩国妇女（平均年龄59.5 ± 6.8岁）的握力与脊柱、股骨颈和全髋的骨密度（BMD）之间的关系，以及握力与先前脆性骨折之间的关系，这些妇女没有影响骨代谢的疾病或药物。在多元回归模型中，年龄和握力与脊柱、股骨颈和全髋关节的骨密度相关。在多元回归模型中，低握力（比值比[OR]，0.925;范围，0.877 - 0.975; P = 0.004）和低股骨颈BMD（OR，0.019;范围，0.001 - 0.354; P = 0.008）是既往脆性骨折的独立预测因子。我们的研究结果表明，低握力与脊柱、股骨颈和全髋骨密度低有关，并与先前脆性骨折的风险增加有关。
Osteoporosis is a widely recognized health problem in postmenopausal women. Osteoporotic fractures reduce independency, limit daily living activities, and increase the mortality rate. Epidemiological studies have demonstrated that low handgrip strength is a risk factor for functional limitations and disabilities, and all-cause mortality. We investigated the relationship between handgrip strength and bone mineral density (BMD) of the spine, femur neck, and total hip, as well the relationship between handgrip strength and previous fragility fractures in 337 healthy postmenopausal Korean women (mean age of 59.5 +/- 6.8 yr) who were free of diseases or medications affecting bone metabolism. Age and handgrip strength were associated with BMD of the spine, femur neck, and total hip in multiple regression models. Low handgrip strength (odds ratio [OR], 0.925; range, 0.877 to 0.975; P = 0.004) and low femur neck BMD (OR, 0.019; range, 0.001 to 0.354; P = 0.008) were independent predictors of previous fragility fractures in a multiple regression model. Our results demonstrate that low handgrip strength is associated with low BMD of the spine, femur neck, and total hip, and with increased risk of previous fragility fractures.