Cancer-treatment-induced neurotoxicity--focus on newer treatments.
Cancer-treatment-induced neurotoxicity--focus on newer treatments.
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DOI：
10.1038/nrclinonc.2015.152
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
DeAngelis LM
中科院分区：
文献类型：
--
作者：
Stone JB;DeAngelis LM
传统的化疗和放疗的神经毒性是公认的。较新的治疗剂如生物和免疫抑制剂的不良反应不太熟悉，它们也与中枢和外周神经系统中的显著神经毒性有关。本文综述了癌症治疗的主要毒性症状，重点是新的治疗方法。认识到这些毒性模式是重要的，因为停药或剂量调整可能会防止进一步的神经损伤。此外，了解这些毒性有助于区分治疗相关症状与癌症进展或神经系统受累。
Neurotoxicity from traditional chemotherapy and radiotherapy is widely recognized. The adverse effects of newer therapeutics such as biological and immunotherapeutic agents are less familiar and they are also associated with significant neurotoxicity in the central and peripheral nervous systems. This review addresses the main toxicities of cancer treatment by symptom with a focus on the newer therapeutics. Recognition of these patterns of toxicity is important as drug discontinuation or dose adjustment may prevent further neurologic injury. Also, knowledge of these toxicities helps to differentiate treatment-related symptoms from progression of cancer or its involvement of the nervous system.
影响因子：
8.8
作者：
Rohatiner, A Z;Prior, P F;Burton, A C;Smith, A T;Balkwill, F R;Lister, T A
通讯作者：
Lister, T A