A reliable method for bonding polydimethylsiloxane (PDMS) to polymethylmethacrylate (PMMA) and its application in micropumps
A reliable method for bonding polydimethylsiloxane (PDMS) to polymethylmethacrylate (PMMA) and its application in micropumps
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DOI：
10.1016/j.snb.2010.09.035
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发表时间：
2010-11-26
影响因子：
8.4
通讯作者：
Nguyen, Nam-Trung
中科院分区：
文献类型：
--
作者：
Tan, Hsih Yin;Loke, Weng Keong;Nguyen, Nam-Trung
聚甲基丙烯酸甲酯（PMMA）因其低成本、高透明度、良好的机械和化学性能而越来越受到微流体研究界的关注。更灵活的聚二甲基硅氧烷（PDMS）非常适合气动驱动。然而，PDMS对气体是可渗透的，并从样品液体中吸收分子。结合PMMA和PDMS将允许微流控装置利用这两种材料的优点。将PMMA与PDMS结合是这种混合方法的关键步骤。本文提出了一种简单、快速、可靠的PMMA与PDMS粘接技术。将25 μ m厚的胶膜（ARclear (R)光学透明胶粘剂8154，adhesive Research, Glen Rock, PA USA）层压在干净的PMMA表面上。随后，将预固化的PDMS混合物旋涂在胶膜上。固化后，粘合剂与PDMS层形成杂化膜。采用精密压力源测试了PDMS/粘接膜的粘接质量和强度。将带微通道的PDMS部件与PDMS/PMMA部件粘接制成蠕动微泵。PDMS/粘接膜作为微型泵的气动执行器。通过电磁阀和控制电子设备将加压空气切换到三个气动执行器。微型泵的流量可高达96 μ l/min。本文报道的技术允许在单个装置中集成由PMMA和PDMS制成的微流控元件。(C) 2010 Elsevier B.V.版权所有
Poly(methylmethacrylate) (PMMA) attracts growing interest in microfluidics research community due to its low cost, high transparency, good mechanical and chemical properties. The more flexible polydimethylsiloxane (PDMS) is well suited for pneumatic actuation. However, PDMS is permeable to gases and absorbs molecules from the sample liquids. Combining PMMA with PDMS would allow a microfluidic device to utilize advantages of both materials. Bonding PMMA to PDMS is a critical step for this hybrid approach. In this paper, we present a simple, fast and reliable technique for bonding PMMA to PDMS. A 25 mu m thick adhesive film (ARclear (R) Optically clear adhesive 8154, Adhesive Research, Glen Rock, PA USA) was laminated onto a clean PMMA surface. Subsequently, pre-cured PDMS mixture was spin coated onto the adhesive film. After curing, the adhesive and the PDMS layer form a hybrid membrane. The bonding quality and the strength of the PDMS/adhesive membrane was tested using a precision pressure source. A peristaltic micropump was fabricated by bonding a PDMS part with microchannels to the PDMS/PMMA part. The PDMS/adhesive membrane acts as the pneumatic actuator for the micropump. Pressurized air was switched to the three pneumatic actuators by solenoid valves and control electronics. The micropumps can achieve a flow rate as high as 96 mu l/min. The techniques reported in this paper allow the integration of microfluidic components made of both PMMA and PDMS in a single device. (C) 2010 Elsevier B.V. All rights reserved.