REGIONAL KETONE-BODY UTILIZATION BY RAT-BRAIN IN STARVATION AND DIABETES
REGIONAL KETONE-BODY UTILIZATION BY RAT-BRAIN IN STARVATION AND DIABETES
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DOI：
10.1152/ajpendo.1986.250.2.e169
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发表时间：
1986-02-01
影响因子：
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通讯作者：
DAVIS, DW
中科院分区：
文献类型：
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作者：
HAWKINS, RA;MANS, AM;DAVIS, DW
酮体（β-羟基丁酸和乙酰乙酸）代谢。这是通过注入β- [3- 14 C]羟基丁酸酯静脉注射，并通过定量放射自显影术测量14 C掺入脑中。大脑利用酮体的能力，以血浆清除率表示，在饥饿和糖尿病中增加约50- 60%血浆清除率在饥饿2天后接近最大值，在饥饿4天、糖尿病6天或糖尿病28天后没有显著增加。在所有情况下，酮体仅为脑能量代谢提供适量的燃料;饥饿2天后为3.2%，糖尿病6天和28天后为6.5%和9.9%。各种结构从酮体中获得的能量需求的分数差别很大。一般来说，端脑利用酮体最多，而后脑利用最少。结构的能量需求（根据进食大鼠的葡萄糖使用量估计）与它们可从酮体获得的能量分数之间不存在相关性。
The rate of ketone body (.beta.-hydroxybutyrate and acetoacetate) metabolism was measured in individual cerebral structures of fed, starved, and diabetic rats. This was done by infusing .beta.-[3-14C]hydroxybutyrate intravenously and measuring the incorporation of 14C into brain by quantitative autoradiography. The capacity of the brain to use ketone bodies, expressed as plasma clearance, increased in starvation and diabetes by .apprx. 50-60%. Plasma clearance was near maximal after 2 days starvation and was not significantly increased after 4 days starvation, 6 days of diabetes or 28 days of diabetes. In all situations the ketone bodies provided only a modest amount of fuel for brain energy metabolism; 3.2% after 2 days starvation and 6.5 and 9.9% after 6 and 28 days of diabetes. The fraction of the energy requirement which the various structures could derive from the ketone bodies differed widely. In general the telencephalon made greatest use of ketone bodies, whereas the hindbrain used least. There was no correlation between the energy requirement of structures (estimated from glucose use in fed rats) and the fraction of energy they could derive from ketone bodies.