Nonpharmacologic Treatment and Prevention Strategies for Dementia
Nonpharmacologic Treatment and Prevention Strategies for Dementia
复制标题
痴呆症的非药物治疗和预防策略
DOI：
--
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
T. Hoang
中科院分区：
文献类型：
--
作者：
K. Yaffe;T. Hoang
综述目的：流行病学研究可以提供重要证据，为非药物干预的时间和持续时间提供信息。虽然需要更多的研究来进一步确定长期的疗效，但支持可改变的风险因素预防的证据是令人信服的，并且将多领域非药物因素纳入的预防策略可能具有最大的影响。生活方式风险因素，如身体、认知和社会活动以及营养、吸烟和饮酒;以及睡眠质量。治疗心血管危险因素的随机对照试验结果并不一致，而增加身体，认知和社会活动的干预措施已证明对痴呆风险具有保护作用。单一营养素膳食补充剂的试验也存在冲突，但对多营养素补充剂的关注显示出希望。观察数据还表明，睡眠质量可能是预防痴呆症的一个可改变的风险因素。
Purpose of Review: Epidemiologic studies can provide critical evidence to inform the timing and duration of nonpharmacologic interventions. Although more studies are needed to further determine long-term efficacy, the evidence supporting modifiable risk factors for prevention is compelling, and prevention strategies that incorporate multidomain nonpharmacologic factors may have the most impact.Recent Findings:Epidemiologic studies have identified a number of promising nonpharmacologic factors that have the potential to lower the risk of developing dementia.Summary:Potential modifiable strategies for dementia prevention include cardiovascular risk factors; lifestyle risk factors such as physical, cognitive, and social activity as well as nutrition, smoking, and alcohol use; and sleep quality. Results of randomized controlled trials for the treatment of cardiovascular risk factors have not been consistent, while interventions that increase physical, cognitive, and social activity have demonstrated protective effects for dementia risk. Trials of single-nutrient dietary supplementation have also been conflicting, but focus on multinutrient supplementation shows promise. Observational data also indicate that sleep quality may be a modifiable risk factor for dementia prevention.
登录
查看更多内容
影响因子：
120.7
作者：
Yaffe, Kristine;Laffan, Alison M.;Harrison, Stephanie Litwack;Redline, Susan;Spira, Adam P.;Ensrud, Kristine E.;Ancoli-Israel, Sonia;Stone, Katie L.
通讯作者：
Stone, Katie L.
影响因子：
120.7
作者：
Yaffe, K;Kanaya, A;Newman, AB
通讯作者：
Newman, AB
影响因子：
120.7
作者：
DeKosky, Steven T.;Williamson, Jeff D.;Fitzpatrick, Annette L.;Kronmal, Richard A.;Ives, Diane G.;Saxton, Judith A.;Lopez, Oscar L.;Burke, Gregory;Carlson, Michelle C.;Fried, Linda P.;Kuller, Lewis H.;Robbins, John A.;Tracy, Russell P.;Woolard, Nancy F.;Dunn, Leslie;Snitz, Beth E.;Nahin, Richard L.;Furberg, Curt D.
通讯作者：
Furberg, Curt D.
影响因子：
--
作者：
Shepardson, Nina E.;Shankar, Ganesh M.;Selkoe, Dennis J.
通讯作者：
Selkoe, Dennis J.
影响因子：
--
作者：
Yaffe, Kristine;Falvey, Cherie;Hamilton, Nathan;Schwartz, Ann V.;Simonsick, Eleanor M.;Satterfield, Suzanne;Cauley, Jane A.;Rosano, Caterina;Launer, Lenore J.;Strotmeyer, Elsa S.;Harris, Tamara B.
通讯作者：
Harris, Tamara B.