Vascular endothelial growth factor and its relationship to inflammatory mediators
Vascular endothelial growth factor and its relationship to inflammatory mediators
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DOI：
10.1158/1078-0432.ccr-06-2416
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发表时间：
2007-05-15
影响因子：
11.5
通讯作者：
Kurzrock, Razelle
中科院分区：
文献类型：
--
作者：
Angelo, Laura S.;Kurzrock, Razelle
炎症是对宿主损伤或感染的反应，是自身免疫性疾病的结果，也是肿瘤发展的反应。虽然免疫系统可能有助于对抗肿瘤，但它也可能助长肿瘤的形成过程。事实上，最近的数据表明，慢性炎症、血管生成和癌症的发展之间存在着强烈的联系。例如，反复感染结核分枝杆菌引起的炎症和疤痕可能是肺癌的原因之一。炎症性乳腺癌表现为血管生成和淋巴管生成增加，比非炎症性乳腺癌有更高的转移潜能。非类固醇抗炎药已被认为是结肠癌和卵巢癌的预防药物。核因子-kappaB的抑制参与了所提出的作用机制。包括白介素6在内的炎性细胞因子是几种癌症的自分泌和旁分泌生长因子，这些细胞因子的高水平可能与预后不良和血管生成因子的产生增加相关。回顾了我们对这种关键相互作用的理解的最新水平。
Inflammation occurs in response to host injury or infection, as the result of an autommune disease, or in response to the development of a tumor. Although the immune system may be helpful in fighting the tumor, it may also fuel the tumorigenic process. In fact, recent data suggest a strong link between chronic inflammation, angiogenesis, and the development of cancer. For example, inflammation and scarring caused by recurring infections with Mycobacterium tuberculosis may be a cause for cancers of the lung. Inflammatory breast cancer exhibits increased angiogenesis and lymphangiogenesis and has a higher metastatic potential than noninflammatory breast cancer. Nonsteroidal anti-inflammatory drugs have been proposed as preventives for the development of colon carcinoma and ovarian cancer. Inhibition of nuclear factor-kappa B contributes to the proposed mechanism of action. Inflammatory cytokines, including interleukin-6, serve as autocrine and paracrine growth factors for several cancers, and high levels of these cytokines may correlate with a poor prognosis and increased production of angiogenic factors. The state of the art of our understanding of this critical interaction is reviewed.