The LifeLines Cohort Study: a resource providing new opportunities for environmental epidemiology.
The LifeLines Cohort Study: a resource providing new opportunities for environmental epidemiology.
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DOI：
10.1186/s13690-016-0144-x
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Stolk RP
中科院分区：
文献类型：
--
作者：
Zijlema WL;Smidt N;Klijs B;Morley DW;Gulliver J;de Hoogh K;Scholtens S;Rosmalen JG;Stolk RP
生命线是一项前瞻性的基于人群的队列研究，调查了荷兰东北地区167，729名参与者中健康老龄化的生物，行为和环境决定因素。家庭和工作地址（历史）的收集和地理编码可以将个人健康数据与详细的接触数据联系起来。我们描述的原因，选择特定的评估环境暴露的生命线，并考虑未来的调查的影响。环境空气污染和道路交通噪音的暴露是使用协调模型估计的。问卷调查收集了关于噪声烦恼、感知电磁场暴露、感知生活环境和邻里特征的数据。为了评估健康和福祉的决定因素，完成了全面的医疗评估和问卷调查。从所有参与者中收集血液和尿液样本，并可获得15，638名参与者的子样本的全基因组关联数据。平均年龄为45岁（标准差（SD）13岁），59%为女性。NO2和PM10的中位数分别为15.7（四分位距（IQR）4.9）μg/m3和24.0（IQR 0.6）μg/m3。日间道路交通噪音的中位数为54.0（IQR 4.2）dB（A）。在生命线中，协调的环境暴露和对健康结果的广泛评估相结合，为环境流行病学提供了巨大的机会。生命线的目标是成为国际科学界的资源。
Lifelines is a prospective population-based cohort study investigating the biological, behavioral and environmental determinants of healthy ageing among 167,729 participants from the North East region of the Netherlands. The collection and geocoding of (history of) home and work addresses allows linkage of individual-level health data to detailed exposure data. We describe the reasons for choosing particular assessments of environmental exposures in LifeLines and consider the implications for future investigations. Exposure to ambient air pollution and road traffic noise was estimated using harmonized models. Data on noise annoyance, perceived exposure to electromagnetic fields, perceived living environment, and neighborhood characteristics were collected with questionnaires. A comprehensive medical assessment and questionnaires were completed in order to assess determinants of health and well-being. Blood and urine samples were collected from all participants and genome wide association data are available for a subsample of 15,638 participants. Mean age was 45 years (standard deviation (SD) 13 years), and 59 % were female. Median levels of NO2 and PM10 were 15.7 (interquartile range (IQR) 4.9) μg/m3 and 24.0 (IQR 0.6) μg/m3 respectively. Median levels of daytime road traffic noise were 54.0 (IQR 4.2) dB(A). The combination of harmonized environmental exposures and extensive assessment of health outcomes in LifeLines offers great opportunities for environmental epidemiology. LifeLines aims to be a resource for the international scientific community.