Trends and correlates of cannabis use in pregnancy: a population-based study in Ontario, Canada from 2012 to 2017
Trends and correlates of cannabis use in pregnancy: a population-based study in Ontario, Canada from 2012 to 2017
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DOI：
10.17269/s41997-018-0148-0
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发表时间：
2019-02-01
影响因子：
4.3
通讯作者：
Walker, Mark
中科院分区：
文献类型：
--
作者：
Corsi, Daniel J.;Hsu, Helen;Walker, Mark
即将进行的立法改革将使加拿大的大麻合法化并使其广泛使用。我们对安大略省的出生登记进行了分析，以确定怀孕期间大麻使用的最新趋势和相关性。方法：我们进行了一项基于人群的回顾性队列研究，该研究汇集了安大略省更好结局登记与网络（BORN）数据库，涵盖2012年4月至2017年12月期间安大略省的活产和死产。使用对数二项回归分析，根据产妇年龄和地区一级社会经济地位（SES）分析怀孕期间自我报告的大麻使用趋势。结果共有10731名妇女报告在怀孕期间使用大麻。患病率从2012年的1.2%上升到2017年的1.8% (p趋势，< 0.001)，相当于相对增加61%（相对危险度[RR] 1.61, 95%可信区间[CI] 1.51 ~ 1.72）。15至24岁妇女和收入最低的两个地区五分位数中，怀孕期间使用大麻的粗流行率为6.7%，而收入最高的三个地区五分位数中，35岁及以上妇女的粗流行率为0.3% （RR 24.59, 95% CI 21.98至27.52）。大多数大麻使用者（52.0%）年龄在15-24岁之间，54.7%的使用者属于收入最低的两个五分位数。自2012年以来，安大略省怀孕期间使用大麻的情况有所增加，据报道，2017年约有2%的孕妇使用大麻。增加的主要是年龄较小的妇女和社会地位较低的妇女，这些群体占用户的一半。促进怀孕期间停止吸食大麻可改善围产期和儿童后期的结局，并减少保健不平等。
Objective Forthcoming legislative changes will legalize and make cannabis widely available in Canada. We conducted an analysis of Ontario's birth registry to determine recent trends and correlates of cannabis use in pregnancy.Methods We conducted a population-based retrospective cohort study assembled from the Better Outcomes Registry & Network (BORN) Ontario database, covering live births and stillbirths in Ontario between April 2012 and December 2017. Trends in self-reported cannabis use in pregnancy were analyzed according to maternal age and area-level socio-economic status (SES) using log binomial regression analysis.Results A total of 10,731 women reported cannabis use in pregnancy. Prevalence increased from 1.2% in 2012 to 1.8% in 2017 (p-trend, < 0.001), equivalent to a relative increase of 61% (relative risk [RR] 1.61, 95% confidence interval [CI] 1.51 to 1.72). The crude prevalence of cannabis use in pregnancy among women aged 15 to 24 years and in the lowest two area-level income quintiles was 6.7%, compared to 0.3% among women aged 35 years and over in the highest three income quintiles (RR 24.59, 95% CI 21.98 to 27.52). A majority (52.0%) of cannabis users were aged 15-24 years and 54.7% of users were in the lowest two income quintiles.Conclusion Cannabis use in pregnancy has increased since 2012 in Ontario and was reported in about 2% of pregnancies in 2017. Increases were predominately among women of younger ages and those of lower SES, and these groups account for half of users. Promoting cannabis cessation in pregnancy could lead to improved perinatal and later childhood outcomes and reduce health inequalities.