ASPIRIN AND COLORECTAL-CANCER - THE LEISURE WORLD COHORT REVISITED
ASPIRIN AND COLORECTAL-CANCER - THE LEISURE WORLD COHORT REVISITED
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DOI：
10.1006/pmed.1995.1020
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发表时间：
1995-03-01
影响因子：
5.1
通讯作者：
PAGANINIHILL, A
中科院分区：
文献类型：
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作者：
PAGANINIHILL, A
休闲世界队列研究中关于阿司匹林和结直肠癌的数据被重新分析，试图解释为什么这项研究是唯一一项阿司匹林似乎没有保护作用的观察性研究。阿司匹林使用者与非使用者在许多基线变量上存在差异，其中一些变量与结直肠癌的风险有关。在对这些变量进行调整后，阿司匹林的使用似乎仍然没有保护作用。《休闲世界》队列研究的受试者年龄明显大于其他研究的受试者;仅限于75岁以下受试者的分析显示，阿司匹林对男性有轻微的保护作用，但对女性没有保护作用。研究开始5年后的重新调查表明，三分之一的受试者改变了阿司匹林的摄入频率。大约25%的日常止痛药使用者报告说，他们使用阿司匹林的主要原因是为了预防心脏病和中风。定期服用阿司匹林，剂量足以预防心血管疾病，可能不足以预防结直肠癌。(C)出版社：Academic Press
The Leisure World Cohort data on aspirin and colorectal cancer was reanalyzed in an attempt to explain why this study is the lone observational study in which aspirin appears not to be protective. Aspirin users differed from nonusers on a number of baseline variables, some of which are related to risk of colorectal cancer. After adjustment for these variables, aspirin use still did not appear to be protective. The Leisure World cohort members are consideraly older than subjects in the other studies; analyses limited to subjects younger than 75 years showed a slightly protective effect of aspirin in men but not in women. A resurvey 5 years after the start of the study indicated that one-third of the subjects had changed the frequency of their aspirin intake. About 25% of daily analgesic users reported their primary reason for using aspirin to be for preventing heart disease and stroke. Regular aspirin use at a dose adequate for preventing cardiovascular disease may be insufficient for preventing colorectal cancer. (C) 1995 Academic Press, Inc.