INHIBITION OF PASSIVE LOCALIZED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY INTERFERON
INHIBITION OF PASSIVE LOCALIZED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY INTERFERON
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DOI：
10.1159/000234836
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
SOWINSKI, R
中科院分区：
文献类型：
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作者：
ABREU, SL;TONDREAU, J;SOWINSKI, R
最近的研究表明，干扰素（IFN）抑制主动免疫刘易斯大鼠的实验性变态反应性脑脊髓炎（EAE）。IFN对被动转移的EAE局部形式的影响进行了研究。通过将EAE淋巴结细胞注射到3天前制备有热脑损伤的大鼠中，获得疾病的定位和加速。在细胞转移24小时内，在脑中观察到小静脉周围淋巴细胞浸润（EAE病变）。在EAE淋巴结细胞注射后立即给予IFN（40，000 U/kg）导致EAE病变显著减少或消除。IFN只作用于传入弧的可能性被排除。干扰素可能通过调节传出弧的成分起作用，尽管不是唯一的作用。IFN在肾上腺切除动物中抑制EAE同样有效。这表明本研究中观察到的免疫抑制作用不是由于内源性产生的皮质类固醇。
Recent studies have shown that inferferon (IFN) suppresses experimental allergic encephalomyelitis (EAE) in actively immunized Lewis rats. The effect of IFN on a localized form of passively transferred EAE was investigated. Localization and acceleration of the disease was obtained by injection of EAE lymph node cells into rats which had, 3 days previously, been prepared with a thermal brain injury. Within 24 h of cell transfer perivenular lymphocytic infiltrates (EAE lesions) were observed in the brain. Administration of IFN (40,000 U/kg) right after EAE lymph node cell injection resulted in a significant reduction or elimination of EAE lesions. The possibility that IFN is acting exclusively on the afferent arc is eliminated. IFN may be acting, although not solely, through modulations of components of the efferent arc. IFN was equally effective in suppressing EAE in adrenalectomized animals. This demonstrates that the immunosuppressive effects observed in this study are not due to endogenously produced corticosteroids.