Association of Family History of HBV with Resectability of Hepatocellular Carcinoma
Association of Family History of HBV with Resectability of Hepatocellular Carcinoma
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DOI：
10.5754/hge11341
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发表时间：
2012-03-01
影响因子：
--
通讯作者：
Zheng, Shusen
中科院分区：
文献类型：
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作者：
Hu, Zhenhua;Li, Zhiwei;Zheng, Shusen
背景/目的：本研究旨在探讨中国人群中肝癌或乙型肝炎病毒（HBV）感染阳性家族史与肝细胞癌（HCC）手术切除率之间的关系。方法：262 名 HCC 患者在我院接受了手术或非手术治疗。其中一百一十八名患者在临床上被认为是可切除的患者。其余 144 名患者临床上无法切除。统计分析在SPSS 15.0 for Windows中进行。结果：HBV 感染家族史与 HCC 的可切除性显着相关（AOR=2.332；95% CI，1.051-5.177）。一级亲属感染HBV与HCC的可切除性也有显着相关性（AOR=2.334；95% CI，1.050-5.190），尤其是患者的兄弟姐妹有HBV感染史与HCC的可切除性显着相关（AOR=2.727；95% CI，1.092-6.808）。结论： HBV 感染家族史与 HCC 的可切除性相关，特别是，如果患者的兄弟姐妹有 HBV 感染史，则表明接受根治性肝切除术的机会减少。
Background/Aims: This study aims to address the relationship between a positive family history of liver cancer or hepatitis B virus (HBV) infection and the operative resectability of hepatocellular carcinoma (HCC) in the Chinese population. Methodology: Two hundred and sixty-two HCC patients underwent operative or non-operative therapies in our hospital. One hundred and eighteen of the patients were clinically considered as resectable patients. The remaining 144 patients were clinically unresectable. Statistical analysis was performed in SPSS 15.0 for Windows. Results: A family history of HBV infection is significantly associated with the resectability of HCC (AOR=2.332; 95% CI, 1.051-5.177). There was also has a significant association between the first degree relatives infected with HBV and the resectability of HCC (AOR=2.334; 95% CI, 1.050-5.190), especially a patient's sibling having a history of HBV infection is significantly related to the resectability of HCC (AOR=2.727; 95% CI, 1.092-6.808). Conclusions: A family history of HBV infection is associated with the resectability of HCC, and in particular, if a patient's sibling has a history of HBV infection, this indicates a reduced opportunity to receive curative liver resection.