Life is a pattern: vascular assembly within the embryo.
Life is a pattern: vascular assembly within the embryo.
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DOI：
10.2741/541
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Moser M
中科院分区：
文献类型：
--
作者：
Heinke J;Patterson C;Moser M
维管系统的形成是发育中胚胎器官发生过程中最早和最重要的事件之一，因为生长的生物体需要运输系统来提供氧气和营养物质并去除废物。两个不同的过程称为血管生成和血管生成导致覆盖整个身体的复杂的血管系统。包括迁移、增殖、分化和成熟在内的几种细胞机制参与产生这种分级血管树。为了实现这一目标，许多信号通路需要在时空模式中被激活和协调。了解胚胎血管生成的分子机制，进一步为成人癌症或缺血性疾病等病理条件下的治疗方法提供了见解。在这篇综述中，我们描述了目前的理解，是必要的和积极的血管发育过程中的主要信号通路。
The formation of the vascular system is one of the earliest and most important events during organogenesis in the developing embryo because the growing organism needs a transportation system to supply oxygen and nutrients and to remove waste products. Two distinct processes termed vasculogenesis and angiogenesis lead to a complex vasculature covering the entire body. Several cellular mechanisms including migration, proliferation, differentiation and maturation are involved in generating this hierarchical vascular tree. To achieve this aim, a multitude of signaling pathways need to be activated and coordinated in spatio-temporal patterns. Understanding embryonic molecular mechanism in angiogenesis further provides insight for therapeutic approaches in pathological conditions like cancer or ischemic diseases in the adult. In this review, we describe the current understanding of major signaling pathways that are necessary and active during vascular development.