Acute Cardiovascular Responses to Vagus Nerve Stimulation after Experimental Spinal Cord Injury.
Acute Cardiovascular Responses to Vagus Nerve Stimulation after Experimental Spinal Cord Injury.
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实验性脊髓损伤后迷走神经刺激的急性心血管反应。
DOI：
10.1089/neu.2019.6828
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发表时间：
2020
影响因子：
4.2
通讯作者：
Hays,SethA
中科院分区：
文献类型：
--
作者：
Sachdeva,Rahul;Krassioukov,AndreiV;Bucksot,JesseE;Hays,SethA
将迷走神经刺激 (VNS) 与康复结合起来已成为增强可塑性和改善一系列神经系统疾病恢复的潜在策略。最近的一项研究强调了 VNS 在促进脊髓损伤 (SCI) 后运动恢复方面的治疗前景。我们研究了慢性 SCI 大鼠模型中急性 VNS 的安全性。我们测量了慢性高位胸部 SCI 后对各种 VNS 模式的心血管反应，众所周知，慢性高位胸部 SCI 会对心血管控制产生有害影响。连续 VNS 的剂量反应实验表明，与对照组相比，心率 (HR) 和血压 (BP) 的敏感性出现 SCI 依赖性增加。临床相关的间歇性 VNS 导致 SCI 大鼠 HR 短暂降低；然而，血压保持不变。在所有实验中，这种效应仅在 VNS 刺激序列存在时持续，因为一旦 VNS 结束，心率和血压就会恢复到基线值。两组均未观察到持续性低血压的长期发作。此外，在刺激期间或之后诱导时，VNS 不会引发自主神经反射异常或加剧自主神经反射异常的严重程度。总体而言，这些发现提供了初步证据，表明用于靶向可塑性治疗（30赫兹，0.8毫安）参数的间歇性 VNS 似乎是安全的，并支持对这种在 SCI 后使用的潜在疗法进行进一步研究。
Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to enhance plasticity and improve recovery in a range of neurological disorders. A recent study highlights the therapeutic promise of VNS in promoting motor recovery after spinal cord injury (SCI). We investigated the safety of acute VNS in a rat model of chronic SCI. We measured the cardiovascular response to various VNS paradigms following chronic high-thoracic SCI that is known to deleteriously impact cardiovascular control. Dose-response experiments with continuous VNS revealed an SCI-dependent increase in sensitivity for heart rate (HR) and blood pressure (BP) compared with controls. A clinically relevant intermittent VNS resulted in transient reduction in HR in rats with SCI; however, BP remained unaltered. In all experiments, the effect lasted only while the VNS stimulus train was present, as HR and BP restored to baseline values as soon as VNS ended. No prolonged episodes of persisting hypotension were seen in either group. Further, VNS did not trigger autonomic dysreflexia or exacerbate the severity of autonomic dysreflexia when induced during or after stimulation sessions. Overall, these findings provide initial evidence that intermittent VNS at parameters used for targeted plasticity therapy (30 Hz, 0.8 mA) appears safe and supports further investigation of this potential therapy for use following SCI.