Organocatalytic direct Michael reaction of ketones and aldehydes with β-nitrostyrene in brine
Organocatalytic direct Michael reaction of ketones and aldehydes with β-nitrostyrene in brine
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DOI：
10.1021/ja060338e
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发表时间：
2006-04-19
影响因子：
15
通讯作者：
Barbas, CF
中科院分区：
文献类型：
--
作者：
Mase, N;Watanabe, K;Barbas, CF
我们已经开发了一种直接的，不对称的迈克尔反应，可以在盐水或海水中进行，而不需要添加有机溶剂。一种具有长疏水烷基链的双功能催化剂，即使在供体与受体的摩尔比相等的情况下，也能有效地催化Michael反应，并以高的对映异构体过量产生所需的产物。
We have developed a direct, asymmetric Michael reaction that can be performed in brine or seawater without addition of organic solvents. A bifunctional catalyst with long hydrophobic alkyl chains efficiently catalyzed Michael reactions and afforded the desired products in excellent yield with high enantiomeric excess, even when only an equal molar ratio of the donor to acceptor was used.