Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer.
Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer.
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DOI：
10.1016/j.biomaterials.2015.04.053
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发表时间：
2015-08
期刊：
影响因子：
14
通讯作者：
Guangbao Yang;Hua Gong;Teng Liu;Xiaoqi Sun;Liang Cheng;Zhuang Liu
中科院分区：
文献类型：
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作者：
Guangbao Yang;Hua Gong;Teng Liu;Xiaoqi Sun;Liang Cheng;Zhuang Liu
将多种成像和治疗功能集成到一个单一的纳米级平台中已被提出是癌症治疗诊断学中有前途的策略。在这项工作中，WS 2纳米片与其表面预吸附与氧化铁（IO）纳米粒子通过自组装包覆有介孔二氧化硅壳，其上连接聚乙二醇（PEG）。所得WS 2-IO@MS-PEG复合纳米粒子表现出许多有趣的固有物理性质，包括高的近红外（NIR）光和X射线吸收，以及强的超顺磁性。同时，WS 2-IO@MS-PEG中的介孔二氧化硅壳可以负载化疗药物多柔比星（DOX），其随后的细胞内释放可以通过NIR诱导的光热加热来触发以增强癌细胞杀伤。在全身施用这种载药的纳米治疗诊断剂后，在荷瘤小鼠中观察到WS 2 - 10 @MS-PEG/DOX的有效肿瘤归巢，如通过三模态荧光、磁共振（MR）和X射线计算机断层扫描（CT）成像所揭示的。然后用WS 2-IO@MS-PEG/DOX进行体内光热与化疗联合，实现了显著优于各自单一疗法的协同治疗效果上级。我们的研究突出了基于二维过渡金属二硫属化物（TMDCs）（如WS 2）开发多功能纳米治疗诊断学的前景，用于多模式成像引导的癌症联合治疗。
Integrating multiple imaging and therapy functionalities into one single nanoscale platform has been proposed to be a promising strategy in cancer theranostics. In this work, WS2nanosheets with their surface pre-adsorbed with iron oxide (IO) nanoparticles via self-assembly are coated with a mesoporous silica shell, on to which polyethylene glycol (PEG) is attached. The obtained WS2-IO@MS-PEG composite nanoparticles exhibit many interesting inherent physical properties, including high near-infrared (NIR) light and X-ray absorbance, as well as strong superparamagnetism. In the mean time, the mesoporous silica shell in WS2-IO@MS-PEG could be loaded with a chemotherapy drug, doxorubicin (DOX), whose intracellular release afterwards may be triggered by NIR-induced photothermal heating for enhanced cancer cell killing. Upon systemic administration of such drug-loaded nano-theranostics, efficient tumor homing of WS2-IO@MS-PEG/DOX is observed in tumor-bearing mice as revealed by three-modal fluorescence, magnetic resonance (MR), and X-ray computed tomography (CT) imaging. In vivo combined photothermal & chemotherapy is then carried out with WS2-IO@MS-PEG/DOX, achieving a remarkably synergistic therapeutic effect superior to the respective mono-therapies. Our study highlights the promise of developing multifunctional nanoscale theranostics based on two-dimensional transition metal dichalcogenides (TMDCs) such as WS2for multimodal imaging-guided combination therapy of cancer.