Induction of luteinizing hormone release by electrochemical stimulation of the medial preoptic area in delta 9-tetrahydrocannabinol-blocked proestrous rats.
Induction of luteinizing hormone release by electrochemical stimulation of the medial preoptic area in delta 9-tetrahydrocannabinol-blocked proestrous rats.
复制标题
通过电化学刺激 Delta 9-四氢大麻酚阻断的发情前大鼠内侧视前区诱导黄体生成激素释放。
DOI：
10.1159/000124569
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发表时间：
1986
影响因子：
4.1
通讯作者：
Tyrey,L
中科院分区：
文献类型：
--
作者：
Murphy,LL;Tyrey,L
大麻的主要精神活性成分Δ-9-四氢大麻酚(THc)在发情前期下午早些时候给予THC(10 mg/kg体重)处理大鼠，可阻止排卵前黄体生成素(LH)激增和排卵。电刺激发情前期大鼠视前内侧区(MPOA)，30、60、90min时，与假刺激对照组比较，刺激后30、60、90min血清LH水平显著升高。诱导的促黄体生成素释放足以引起与仅用药物载体治疗的对照组大鼠的自发排卵相媲美的排卵反应。这些结果与THC通过作用于中枢神经系统而抑制促性腺激素分泌的假说相一致，但表明当LHRH神经分泌单位被脑刺激激活时，THC的中枢抑制作用并不阻止LHRH的释放。因此，THC的抗排卵作用似乎是由于抑制了促黄体生成素的分泌，而不是直接阻断促黄体生成素的释放。
The predominant psychoactive constituent of marijuana, Δ9-tetrahydrocannabinol (THC), blocks the preovulatory luteinizing hormone (LH) surge and ovulation in rats treated with THC (10 mg/kg body weight) during the early afternoon of proestrus. When THC-blocked proestrous rats were subjected to unilateral electrochemical stimulation (100 µA anodal DC for 45 s) in the medial preoptic area (mPOA), serum LH was significantly elevated at 30, 60 and 90 min after stimulation in comparison with LH levels measured in sham-stimulated control animals at those times. The induced LH release was sufficient to elicit ovulatory responses comparable to the spontaneous ovulations observed in control rats treated only with the drug vehicle. These results are consistent with the hypothesis that THC inhibits gonadotropin secretion by action within the central nervous system, but demonstrate that the central inhibitory effect of THC does not prevent the release of LH-releasing hormone (LHRH) when the LHRH neurosecretory units are activated by brain stimulation. Thus, the antiovulatory effect of THC appears to result from.an inhibition of LH secretion which does not involve the direct blockade of LHRH release.