Minimum Important Difference for Validated Instruments in Women With Urge Incontinence
Minimum Important Difference for Validated Instruments in Women With Urge Incontinence
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DOI：
10.1002/nau.21028
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发表时间：
2011-01-01
影响因子：
2
通讯作者：
Lukacz, Emily
中科院分区：
文献类型：
--
作者：
Dyer, Keisha Y.;Xu, Yan;Lukacz, Emily
目的：最小重要差异（MID）估计与主观改善感相关的仪器分数的最小变化程度。本研究的目的是使用锚法和基于分布的方法评估急迫性尿失禁患者的泌尿生殖器窘迫量表（UDI）、排尿影响问卷（IIQ）和膀胱过度活动问卷（OAB-q）的MID，以及MID是否随时间变化。研究方法：这是一项多中心试验的子分析，该试验纳入了307例单纯急迫性（11例）或急迫性为主（296例）尿失禁的女性，这些女性在随机接受抗胆碱能药物联合或不联合行为治疗后10周和8个月完成了特定条件仪器。只有当锚点（改善总体感知（GPI）、患者满意度问卷（PSQ）和失禁发作）与失禁工具（UDI、UDI刺激性子量表、IIQ和OAB-q子量表）之间的Kendall等级相关性>= 0.3时，我们才应用基于锚点的方法。我们对所有工具应用了三种基于分布的方法：效应量为+/- 0.2 SD（小）和+/- 0.5 SD（中），测量标准误为+/- 1。在两个时间点进行分析。结果如下：UDI基于锚点的MID范围为-35至-45，UDI和IIQ基于刺激性子量表分布的方法的MID范围分别为-10至-25和-19至-49，反映了困扰和症状严重程度（SS）的降低。OAB-q子量表MID范围为+5至+12，表示生活质量（HRQL）改善，-13至-25，与SS降低一致。结论：UDI和刺激性UDI的冲动为主UI女性的MID分别为-35和-15。我们的研究结果与以前报道的OAB-q分量表的MID一致。基于分布的方法MID的值低于基于锚点的值。MID通常不会随着时间的推移而变化。Neurorol。Urodynam。30：1319-1324，2011. (C)2011 Wiley-Liss，Inc.
Aims: Minimum important difference (MID) estimates the minimum degree of change in an instrument's score that correlates with subjective sense of improvement. The aim of this study was to estimate the MID for the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ) and Overactive Bladder Questionnaire (OAB-q) using anchor and distribution-based approaches in patients with urge-predominant incontinence and whether MID changes over time. Methods: This was a sub-analysis of a multi-center trial of 307 women with pure urge (11) or urge-predominant (296) incontinence who completed condition-specific instruments 10 weeks and 8 months after randomization to anticholinergic medication with or without behavioral therapy. We applied anchor-based methods only when the Kendall's rank correlations between the anchors (Global Perception of Improvement (GPI), Patient Satisfaction Questionnaire (PSQ), and incontinence episodes) and the incontinence instruments (UDI, UDI irritative subscale, IIQ, and OAB-q subscales) were >= 0.3. We applied three distribution-based methods to all instruments: effect sizes of +/- 0.2 SD (small) and +/- 0.5 SD (medium), and standard error of measurement of +/- 1. Analyses were performed at both time points. Results: Anchor-based MIDs for the UDI ranged from -35 to -45 and -15 to -25 for the irritative subscale distribution-based methods MIDs for UDI and IIQ ranged between -10 to -25 and -19 to -49, respectively, reflective of a reduction in bother and symptom severity (SS). OAB-q subscale MIDs ranged from +5 to +12, denoting improved quality of life (HRQL) and -13 to -25, consistent with a reduction in SS. Conclusions: The MID in women with urge-predominant UI for the UDI and UDI irritative are -35 and -15. Our findings are consistent with previously reported MIDs for the OAB-q subscales. Distribution-based method MIDs are lower values than anchor-based values. The MID did not typically change over the time. Neurourol. Urodynam. 30:1319-1324, 2011. (C) 2011 Wiley-Liss, Inc.