EVOLUTIONARY TREES FROM DNA-SEQUENCES - A MAXIMUM-LIKELIHOOD APPROACH
EVOLUTIONARY TREES FROM DNA-SEQUENCES - A MAXIMUM-LIKELIHOOD APPROACH
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DOI：
10.1007/bf01734359
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发表时间：
1981-01-01
影响因子：
3.9
通讯作者：
FELSENSTEIN, J
中科院分区：
文献类型：
--
作者：
FELSENSTEIN, J
讨论了最大似然技术在从核酸序列数据估计进化树中的应用。提出了一种计算上可行的方法来求这种极大似然估计，并编制了计算机程序。与传统的简约算法相比，该方法具有优势，如果不同谱系的进化速度不同，则可能会给出误导性的结果。它还允许通过似然比检验来检验关于进化速率的不变性的假设，并粗略地指示树的估计的误差。
The application of maximum likelihood techniques to the estimation of evolutionary trees from nucleic acid sequence data is discussed. A computationally feasible method for finding such maximum likelihood estimates is developed, and a computer program is available. This method has advantages over the traditional parsimony algorithms, which can give misleading results if rates of evolution differ in different lineages. It also allows the testing of hypotheses about the constancy of evolutionary rates by likelihood ratio tests, and gives rough indication of the error of the estimate of the tree.