The action of phlorrhizin on the intestinal transfer of glucose and water in vitro
The action of phlorrhizin on the intestinal transfer of glucose and water in vitro
复制标题
根根苷对体外葡萄糖和水肠道转运的作用
DOI：
10.1113/jphysiol.1958.sp006109
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发表时间：
1958
期刊：
影响因子：
--
通讯作者：
C. B. Taylor
中科院分区：
文献类型：
--
作者：
B. Parsons;D. Smyth;C. B. Taylor
根根苷对肠道葡萄糖吸收的抑制作用早已为人所知，Fisher & Parsons (1950)表明这种抑制作用也可以在体外获得。 Jervis、Johnson、Sheff 和 Smyth (1956) 以及 Smyth 和 Taylor (1955a，1957) 研究了极小浓度的根根苷对葡萄糖和水运输的影响。进行以下实验以进一步研究根根苷对葡萄糖和水运输的抑制，并找出这些抑制是否与根根苷对肠道代谢的影响有关。选择氧消耗量、葡萄糖利用量和乳酸产生量作为代谢活动的指标，并研究了不同浓度的根根苷对这些指标的影响，以及对肠道运输水和葡萄糖的能力的影响。本文是 Smyth & Taylor (1955b) 初步报告的放大和延伸。
The inhibitory effect of phlorrhizin on the intestinal absorption of glucose has long been known, and Fisher & Parsons (1950) showed that the inhibition could also be obtained in vitro. The effect of very small concentrations of phlorrhizin on the transport of glucose and of water has been studied by Jervis, Johnson, Sheff & Smyth (1956) and by Smyth & Taylor (1955a, 1957). The following experiments were undertaken to investigate further the inhibition by phlorrhizin of glucose and water transport and to find whether these inhibitions could be related to the effect of phlorrhizin on the metabolism of the intestine. As indices of metabolic activity oxygen consumption, glucose utilization and lactic acid production were chosen, and studies were made of the effects of various concentrations of phlorrhizin on these, and on the capacity of the intestine to transport water and glucose. The present paper is an amplification and extension of a preliminary report of Smyth & Taylor (1955b).