The Association Between Maternal Oxidative Stress at Mid-Gestation and Subsequent Pregnancy Complications
The Association Between Maternal Oxidative Stress at Mid-Gestation and Subsequent Pregnancy Complications
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DOI：
10.1177/1933719111426601
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发表时间：
2012-05-01
影响因子：
2.9
通讯作者：
Hung, Tai-Ho
中科院分区：
文献类型：
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作者：
Hsieh, T'sang-T'ang;Chen, Szu-Fu;Hung, Tai-Ho
目的：探讨妊娠中期母亲氧化应激与随后妊娠并发症发生之间的关系。研究设计：共有 503 名健康孕妇提供了妊娠 24 至 26 周时的血液和尿液样本，并在产后进行前瞻性随访。这些样本用于评估多种氧化应激标志物，包括血浆总抗氧化能力、8-异前列烷、红细胞谷胱甘肽过氧化物酶和超氧化物歧化酶活性，以及尿 8-羟基脱氧鸟苷 (8-OHdG)。结果：与妊娠无并发症的女性相比，发生先兆子痫 (P = .008) 和小于胎龄儿 (P = .002) 的女性血浆 8-异前列烷水平显着升高，而随后生育低出生体重新生儿的女性尿 8-OHdG 浓度也更高（
Objective: To investigate the association between maternal oxidative stress at mid-gestation and subsequent development of pregnancy complications. Study design: A total of 503 healthy pregnant women provided their blood and urine samples at 24 to 26 weeks of gestation and were prospectively followed through postpartum. These samples were used to assess a variety of oxidative stress markers, including plasma total antioxidant capacity, 8-isoprostane, erythrocyte glutathione peroxidase and superoxide dismutase activity, and urinary 8-hydroxydeoxyguanosine (8-OHdG). Results: Compared with women with uncomplicated pregnancies, significantly higher plasma 8-isoprostane levels were noted in women who developed preeclampsia (P = .008) and small-for-gestational age infants (P = .002), while higher urinary 8-OHdG concentrations were noted in women who subsequently had low-birth-weight neonates (