TYPE-SPECIFIC HUMAN PAPILLOMAVIRUS DNA IN ABNORMAL SMEARS AS A PREDICTOR OF HIGH-GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA
TYPE-SPECIFIC HUMAN PAPILLOMAVIRUS DNA IN ABNORMAL SMEARS AS A PREDICTOR OF HIGH-GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA
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DOI：
10.1038/bjc.1994.28
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发表时间：
1994-01-01
影响因子：
8.8
通讯作者：
ANDERSON, M
中科院分区：
文献类型：
--
作者：
CUZICK, J;TERRY, G;ANDERSON, M
采用聚合酶链反应对133例因涂片异常而接受阴道镜检查的妇女的脱落细胞进行人乳头瘤病毒（HPV）分型和定量。高水平的HPV 16正确预测宫颈上皮内瘤变（CIN）的发生率为93%的II-III级，但只有59%的CIN III病例与高水平的HPV 16相关。84%的CIN III病变含有高水平的HPV 16、18、31、33和35型中的至少一种，但其他类型对CIN III的特异性低于HPV 16。总体而言，HPV检测在预测高级别CIN病变方面优于细胞学检查，但似乎两种方法的某种组合将产生比单独使用更好的性能。特别是，HPV检测似乎有助于确定哪些涂片轻度异常的女性有需要立即转诊进行阴道镜检查的高级别潜在病变。
Human papillomavirus (HPV) typing and quantitation by polymerase chain reaction was performed on exfoliated cells from 133 women referred for colposcopy because of an abnormal smear. High levels of HPV 16 correctly predicted cervical intraepithelial neoplasia (CIN) grade II-III in 93% of its occurrences, but only 59% of cases of CIN III were associated with high levels of this type. Eighty-four per cent of CIN III lesions contained high levels of at least one of HPV types 16, 18, 31, 33 and 35, but the other types were less specific for CIN III than HPV 16. Overall HPV testing compared favourably with cytology for predicting high-grade CIN lesions, but it would appear that some combination of the two modalities will produce better performance than either alone. In particular, HPV testing appears to be helpful in determining which women with mildly abnormal smears have high-grade underlying lesions in need of immediate referral for colposcopy.